Abstract

Zygomycosis is an invasive mycotic disease caused by fungi in the class Zygomycetes. Within this class, the most common species associated with infection include Absidia corymbifera, Apophysomyces elegans, Cunninghamella bertholletiae, Rhizomucor pusillus, Rhizopus microsporus var. rhizopodiformis, and Rhizopus arrhizus. These fungi all produce characteristic hyphal forms in tissue that are variable in width, produce haphazard branching, and lack septation. Although these fungi are ubiquitous in the environment, they are opportunists causing invasive disease in compromised hosts with a high mortality even when aggressive antifungal therapy and surgical intervention are utilized. Clinically, the disease most often affects the sinus with or without pulmonary involvement; direct extension from sinuses into cerebral tissue is not uncommon. This article describes the general clinical features of zygomycosis, with an emphasis on management in the setting of immunosuppression.

Original languageEnglish (US)
Pages (from-to)221-231
Number of pages11
JournalSeminars in Respiratory and Critical Care Medicine
Volume25
Issue number2
DOIs
StatePublished - Apr 1 2004

Fingerprint

Zygomycosis
Rhizopus
Bertholletia
Fungi
Absidia
Cunninghamella
Rhizomucor
Mycoses
Immunosuppression
Lung
Mortality
Infection
Therapeutics

Keywords

  • Fungal infection
  • Immunocompromised host
  • Mucor
  • Zygomycosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Zygomycosis. / Freifeld, Alison Gail; Iwen, Peter Charles.

In: Seminars in Respiratory and Critical Care Medicine, Vol. 25, No. 2, 01.04.2004, p. 221-231.

Research output: Contribution to journalReview article

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