Zinc absorption following massive small-bowel resection in the rat

Dean Lowell Antonson, Jon A. Vanderhoof

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Zinc absorption was evaluated six weeks after massive small-bowel resection in rats. Forty rats were divided into four groups. Ten were subjected to proximal small-bowel resection, 10 to distal resection, and 20 served as pair-fed controls. Intestinal perfusion studies were performed using a recirculation technique. Twenty ml of a solution containing 10 μg/ml of zinc as zinc sulfate, isotonic sodium chloride, and polyethylene glycol 5 g/liter was perfused for 2 hr through 10 cm of remaining bowel in resected animals and comparable segments in control animals. Zinc uptake was determined and expressed per 0.1 g mucosal dry weight. In control animals, zinc absorption was greatest in the ileum. Animals undergoing distal bowel resection had a compensatory increase in zinc absorption in the proximal small intestine. However, animals undergoing proximal resection did not demonstrate an increase in zinc absorption in the distal bowel. The proximal small intestine appears capable of increasing its capacity for zinc absorption in the response to distal small-bowel resection.

Original languageEnglish (US)
Pages (from-to)789-793
Number of pages5
JournalDigestive Diseases and Sciences
Volume27
Issue number9
DOIs
StatePublished - Sep 1 1982

Fingerprint

Zinc
Small Intestine
Zinc Sulfate
Ileum
Sodium Chloride
Perfusion
Weights and Measures

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Zinc absorption following massive small-bowel resection in the rat. / Antonson, Dean Lowell; Vanderhoof, Jon A.

In: Digestive Diseases and Sciences, Vol. 27, No. 9, 01.09.1982, p. 789-793.

Research output: Contribution to journalArticle

Antonson, Dean Lowell ; Vanderhoof, Jon A. / Zinc absorption following massive small-bowel resection in the rat. In: Digestive Diseases and Sciences. 1982 ; Vol. 27, No. 9. pp. 789-793.
@article{4997cbf1898a43858b132f022c3b9395,
title = "Zinc absorption following massive small-bowel resection in the rat",
abstract = "Zinc absorption was evaluated six weeks after massive small-bowel resection in rats. Forty rats were divided into four groups. Ten were subjected to proximal small-bowel resection, 10 to distal resection, and 20 served as pair-fed controls. Intestinal perfusion studies were performed using a recirculation technique. Twenty ml of a solution containing 10 μg/ml of zinc as zinc sulfate, isotonic sodium chloride, and polyethylene glycol 5 g/liter was perfused for 2 hr through 10 cm of remaining bowel in resected animals and comparable segments in control animals. Zinc uptake was determined and expressed per 0.1 g mucosal dry weight. In control animals, zinc absorption was greatest in the ileum. Animals undergoing distal bowel resection had a compensatory increase in zinc absorption in the proximal small intestine. However, animals undergoing proximal resection did not demonstrate an increase in zinc absorption in the distal bowel. The proximal small intestine appears capable of increasing its capacity for zinc absorption in the response to distal small-bowel resection.",
author = "Antonson, {Dean Lowell} and Vanderhoof, {Jon A.}",
year = "1982",
month = "9",
day = "1",
doi = "10.1007/BF01391371",
language = "English (US)",
volume = "27",
pages = "789--793",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer New York",
number = "9",

}

TY - JOUR

T1 - Zinc absorption following massive small-bowel resection in the rat

AU - Antonson, Dean Lowell

AU - Vanderhoof, Jon A.

PY - 1982/9/1

Y1 - 1982/9/1

N2 - Zinc absorption was evaluated six weeks after massive small-bowel resection in rats. Forty rats were divided into four groups. Ten were subjected to proximal small-bowel resection, 10 to distal resection, and 20 served as pair-fed controls. Intestinal perfusion studies were performed using a recirculation technique. Twenty ml of a solution containing 10 μg/ml of zinc as zinc sulfate, isotonic sodium chloride, and polyethylene glycol 5 g/liter was perfused for 2 hr through 10 cm of remaining bowel in resected animals and comparable segments in control animals. Zinc uptake was determined and expressed per 0.1 g mucosal dry weight. In control animals, zinc absorption was greatest in the ileum. Animals undergoing distal bowel resection had a compensatory increase in zinc absorption in the proximal small intestine. However, animals undergoing proximal resection did not demonstrate an increase in zinc absorption in the distal bowel. The proximal small intestine appears capable of increasing its capacity for zinc absorption in the response to distal small-bowel resection.

AB - Zinc absorption was evaluated six weeks after massive small-bowel resection in rats. Forty rats were divided into four groups. Ten were subjected to proximal small-bowel resection, 10 to distal resection, and 20 served as pair-fed controls. Intestinal perfusion studies were performed using a recirculation technique. Twenty ml of a solution containing 10 μg/ml of zinc as zinc sulfate, isotonic sodium chloride, and polyethylene glycol 5 g/liter was perfused for 2 hr through 10 cm of remaining bowel in resected animals and comparable segments in control animals. Zinc uptake was determined and expressed per 0.1 g mucosal dry weight. In control animals, zinc absorption was greatest in the ileum. Animals undergoing distal bowel resection had a compensatory increase in zinc absorption in the proximal small intestine. However, animals undergoing proximal resection did not demonstrate an increase in zinc absorption in the distal bowel. The proximal small intestine appears capable of increasing its capacity for zinc absorption in the response to distal small-bowel resection.

UR - http://www.scopus.com/inward/record.url?scp=0019988422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019988422&partnerID=8YFLogxK

U2 - 10.1007/BF01391371

DO - 10.1007/BF01391371

M3 - Article

VL - 27

SP - 789

EP - 793

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 9

ER -