Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (meriones unguiculatus)

Liju Luan, Chaoran Ren, Benson Wui Man Lau, Jian Yang, Gary E Pickard, Kwok Fai So, Mingliang Pu

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: The dorsal raphe nucleus (DRN) of the mesencephalon is a complex multi-functional and multi-transmitter nucleus involved in a wide range of behavioral and physiological processes. The DRN receives a direct input from the retina. However little is known regarding the type of retinal ganglion cell (RGC) that innervates the DRN. We examined morphological characteristics and physiological properties of these DRN projecting ganglion cells. Methodology/Principal Findings: The Mongolian gerbils are highly visual rodents with a diurnal/crepuscular activity rhythm. It has been widely used as experimental animals of various studies including seasonal affective disorders and depression. Young adult gerbils were used in the present study. DRN-projecting RGCs were identified following retrograde tracer injection into the DRN, characterized physiologically by extracellular recording and morphologically after intracellular filling. The result shows that DRN-projecting RGCs exhibit morphological characteristics typical of alpha RGCs and physiological response properties of Y-cells. Melanopsin was not detected in these RGCs and they show no evidence of intrinsic photosensitivity. Conclusions/Significance: These findings suggest that RGCs with alpha-like morphology and Y-like physiology appear to perform a non-imaging forming function and thus may participate in the modulation of DRN activity which includes regulation of sleep and mood.

Original languageEnglish (US)
Article numbere18938
JournalPloS one
Volume6
Issue number4
DOIs
StatePublished - May 12 2011

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Meriones unguiculatus
Photosensitivity
Retinal Ganglion Cells
Gerbillinae
Physiology
Transmitters
Animals
Modulation
diurnal activity
gerbils
cells
emotions
sleep
young adults
retina
physiological response
laboratory animals
tracer techniques
rodents
physiology

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (meriones unguiculatus). / Luan, Liju; Ren, Chaoran; Lau, Benson Wui Man; Yang, Jian; Pickard, Gary E; So, Kwok Fai; Pu, Mingliang.

In: PloS one, Vol. 6, No. 4, e18938, 12.05.2011.

Research output: Contribution to journalArticle

Luan, Liju ; Ren, Chaoran ; Lau, Benson Wui Man ; Yang, Jian ; Pickard, Gary E ; So, Kwok Fai ; Pu, Mingliang. / Y-like retinal ganglion cells innervate the dorsal raphe nucleus in the Mongolian gerbil (meriones unguiculatus). In: PloS one. 2011 ; Vol. 6, No. 4.
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