World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction

A. Villa, A. Wolff, Nagamani Narayana, C. Dawes, D. J. Aframian, A. M. Lynge Pedersen, A. Vissink, A. Aliko, Y. W. Sia, R. K. Joshi, R. McGowan, S. B. Jensen, A. R. Kerr, J. Ekström, G. Proctor

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

The aim of this paper was to perform a systematic review of the pathogenesis of medication-induced salivary gland dysfunction (MISGD). Review of the identified papers was based on the standards regarding the methodology for systematic reviews set forth by the World Workshop on Oral Medicine IV and the PRISMA statement. Eligible papers were assessed for both the degree and strength of relevance to the pathogenesis of MISGD as well as on the appropriateness of the study design and sample size. A total of 99 papers were retained for the final analysis. MISGD in human studies was generally reported as xerostomia (the sensation of oral dryness) without measurements of salivary secretion rate. Medications may act on the central nervous system (CNS) and/or at the neuroglandular junction on muscarinic, α-and β-adrenergic receptors and certain peptidergic receptors. The types of medications that were most commonly implicated for inducing salivary gland dysfunction were those acting on the nervous, cardiovascular, genitourinary, musculoskeletal, respiratory, and alimentary systems. Although many medications may affect the salivary flow rate and composition, most of the studies considered only xerostomia. Thus, further human studies are necessary to improve our understanding of the association between MISGD and the underlying pathophysiology.

Original languageEnglish (US)
Pages (from-to)365-382
Number of pages18
JournalOral Diseases
Volume22
Issue number5
DOIs
StatePublished - Jul 1 2016

Fingerprint

Oral Medicine
Salivary Glands
Xerostomia
Education
Urogenital System
Digestive System
Musculoskeletal System
Muscarinic Receptors
Cardiovascular System
Respiratory System
Sample Size
Adrenergic Receptors
Nervous System
Central Nervous System

Keywords

  • pathogenesis
  • physiology
  • saliva
  • salivary glands

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Villa, A., Wolff, A., Narayana, N., Dawes, C., Aframian, D. J., Lynge Pedersen, A. M., ... Proctor, G. (2016). World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction. Oral Diseases, 22(5), 365-382. https://doi.org/10.1111/odi.12402

World Workshop on Oral Medicine VI : a systematic review of medication-induced salivary gland dysfunction. / Villa, A.; Wolff, A.; Narayana, Nagamani; Dawes, C.; Aframian, D. J.; Lynge Pedersen, A. M.; Vissink, A.; Aliko, A.; Sia, Y. W.; Joshi, R. K.; McGowan, R.; Jensen, S. B.; Kerr, A. R.; Ekström, J.; Proctor, G.

In: Oral Diseases, Vol. 22, No. 5, 01.07.2016, p. 365-382.

Research output: Contribution to journalReview article

Villa, A, Wolff, A, Narayana, N, Dawes, C, Aframian, DJ, Lynge Pedersen, AM, Vissink, A, Aliko, A, Sia, YW, Joshi, RK, McGowan, R, Jensen, SB, Kerr, AR, Ekström, J & Proctor, G 2016, 'World Workshop on Oral Medicine VI: a systematic review of medication-induced salivary gland dysfunction', Oral Diseases, vol. 22, no. 5, pp. 365-382. https://doi.org/10.1111/odi.12402
Villa, A. ; Wolff, A. ; Narayana, Nagamani ; Dawes, C. ; Aframian, D. J. ; Lynge Pedersen, A. M. ; Vissink, A. ; Aliko, A. ; Sia, Y. W. ; Joshi, R. K. ; McGowan, R. ; Jensen, S. B. ; Kerr, A. R. ; Ekström, J. ; Proctor, G. / World Workshop on Oral Medicine VI : a systematic review of medication-induced salivary gland dysfunction. In: Oral Diseases. 2016 ; Vol. 22, No. 5. pp. 365-382.
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