Workshop report:Modeling the molecularmechanism of bacterial spore germination and elucidating reasons for germination heterogeneity

Karl J. Indest, Wallace G. Buchholz, Jim R. Faeder, Peter Setlow

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germinationwere presented and evaluated. As a result of these interactions, future research directionswere defined, the outcome of which should result in a robustmodel to help define themolecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores.

Original languageEnglish (US)
Pages (from-to)R73-R78
JournalJournal of food science
Volume74
Issue number6
DOIs
StatePublished - Aug 1 2009

Fingerprint

Bacterial Spores
bacterial spores
spore germination
Germination
Spores
spores
germination
Education
decontamination
bioinformatics
researchers
Biological Sciences
Decontamination
Computational Biology
Research Personnel

Keywords

  • Bacterial spores
  • Microbial survival
  • Modeling

ASJC Scopus subject areas

  • Food Science

Cite this

Workshop report:Modeling the molecularmechanism of bacterial spore germination and elucidating reasons for germination heterogeneity. / Indest, Karl J.; Buchholz, Wallace G.; Faeder, Jim R.; Setlow, Peter.

In: Journal of food science, Vol. 74, No. 6, 01.08.2009, p. R73-R78.

Research output: Contribution to journalReview article

@article{c5279e95af184c46a08e272e8f08e592,
title = "Workshop report:Modeling the molecularmechanism of bacterial spore germination and elucidating reasons for germination heterogeneity",
abstract = "Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germinationwere presented and evaluated. As a result of these interactions, future research directionswere defined, the outcome of which should result in a robustmodel to help define themolecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores.",
keywords = "Bacterial spores, Microbial survival, Modeling",
author = "Indest, {Karl J.} and Buchholz, {Wallace G.} and Faeder, {Jim R.} and Peter Setlow",
year = "2009",
month = "8",
day = "1",
doi = "10.1111/j.1750-3841.2009.01245.x",
language = "English (US)",
volume = "74",
pages = "R73--R78",
journal = "Journal of Food Science",
issn = "0022-1147",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Workshop report:Modeling the molecularmechanism of bacterial spore germination and elucidating reasons for germination heterogeneity

AU - Indest, Karl J.

AU - Buchholz, Wallace G.

AU - Faeder, Jim R.

AU - Setlow, Peter

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germinationwere presented and evaluated. As a result of these interactions, future research directionswere defined, the outcome of which should result in a robustmodel to help define themolecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores.

AB - Over the course of 2 days, top researchers in the fields of bacterial spore biology and computational biology discussed approaches to determine the cause of spore germination heterogeneity. Biological and mathematical data gaps were identified, and experimental approaches and computational strategies for modeling spore germinationwere presented and evaluated. As a result of these interactions, future research directionswere defined, the outcome of which should result in a robustmodel to help define themolecular mechanism(s) of spore germination. Mechanistic understanding of germination will be instrumental for developing novel sterilization, treatment, and decontamination strategies to mitigate threats posed by spores.

KW - Bacterial spores

KW - Microbial survival

KW - Modeling

UR - http://www.scopus.com/inward/record.url?scp=70350168279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70350168279&partnerID=8YFLogxK

U2 - 10.1111/j.1750-3841.2009.01245.x

DO - 10.1111/j.1750-3841.2009.01245.x

M3 - Review article

C2 - 19723224

AN - SCOPUS:70350168279

VL - 74

SP - R73-R78

JO - Journal of Food Science

JF - Journal of Food Science

SN - 0022-1147

IS - 6

ER -