WHO/IUIS Allergen Nomenclature: Providing a common language

on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.

Original languageEnglish (US)
Pages (from-to)3-13
Number of pages11
JournalMolecular Immunology
Volume100
DOIs
StatePublished - Aug 2018

Fingerprint

Terminology
Allergens
Language
Names
Databases
Immunoglobulin E
Publications
Biochemical Phenomena
Proteins
Wetlands
Hypersensitivity
Technology
Antigens

Keywords

  • Allergen database
  • IgE
  • Isoallergen
  • Taxonomic name
  • WHO/IUIS Allergen Nomenclature

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

Cite this

on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee (2018). WHO/IUIS Allergen Nomenclature: Providing a common language. Molecular Immunology, 100, 3-13. https://doi.org/10.1016/j.molimm.2018.03.003

WHO/IUIS Allergen Nomenclature : Providing a common language. / on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee.

In: Molecular Immunology, Vol. 100, 08.2018, p. 3-13.

Research output: Contribution to journalArticle

on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee 2018, 'WHO/IUIS Allergen Nomenclature: Providing a common language', Molecular Immunology, vol. 100, pp. 3-13. https://doi.org/10.1016/j.molimm.2018.03.003
on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee. WHO/IUIS Allergen Nomenclature: Providing a common language. Molecular Immunology. 2018 Aug;100:3-13. https://doi.org/10.1016/j.molimm.2018.03.003
on behalf of the WHO IUIS Allergen Nomenclature Sub-Committee. / WHO/IUIS Allergen Nomenclature : Providing a common language. In: Molecular Immunology. 2018 ; Vol. 100. pp. 3-13.
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abstract = "A systematic nomenclature for allergens originated in the early 1980s, when few protein allergens had been described. A group of scientists led by Dr. David G. Marsh developed a nomenclature based on the Linnaean taxonomy, and further established the World Health Organization/International Union of Immunological Societies (WHO/IUIS) Allergen Nomenclature Sub-Committee in 1986. Its stated aim was to standardize the names given to the antigens (allergens) that caused IgE-mediated allergies in humans. The Sub-Committee first published a revised list of allergen names in 1986, which continued to grow with rare publications until 1994. Between 1994 and 2007 the database was a text table online, then converted to a more readily updated website. The allergen list became the Allergen Nomenclature database (www.allergen.org), which currently includes approximately 880 proteins from a wide variety of sources. The Sub-Committee includes experts on clinical and molecular allergology. They review submissions of allergen candidates, using evidence-based criteria developed by the Sub-Committee. The review process assesses the biochemical analysis and the proof of allergenicity submitted, and aims to assign allergen names prior to publication. The Sub-Committee maintains and revises the database, and addresses continuous challenges as new “omics” technologies provide increasing data about potential new allergens. Most journals publishing information on new allergens require an official allergen name, which involves submission of confidential data to the WHO/IUIS Allergen Nomenclature Sub-Committee, sufficient to demonstrate binding of IgE from allergic subjects to the purified protein.",
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