What is the relationship between gestational age and docosahexaenoic acid (DHA) and arachidonic acid (ARA) levels?

Michelle Baack, Susan E. Puumala, Stephen E. Messier, Deborah K. Pritchett, William S. Harris

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Long chain polyunsaturated fatty acids (LCPUFA) including docosahexaenoic acid (DHA) and arachidonic acid (ARA) are increasingly transferred from mother to fetus late in pregnancy. Infants born before this transfer is complete are at risk for deficiency. This study determines the relationship between gestational age (GA) and circulating LCPUFA levels to better understand the unique needs of premature infants born at various GAs. Whole blood was collected within the first 7 days of life from 60 preterm (≤34 weeks GA) and 30 term infants (≥38 weeks GA) and FA levels were analyzed. Since concurrent intravenous lipid emulsion can skew composition data, blood LCPUFA concentrations were also measured. Levels were compared among groups, and linear regression models were used to examine the association between FA composition and GA. Preterm infants had significantly lower DHA and ARA levels than term peers, and whether assessed as concentrations or compositions, both directly correlated with GA (p<0.0001). Moreover, FA comparisons suggest that premature infants have impaired synthesis of LCPUFAs from precursors and may require preformed DHA and ARA. This study confirms that essential FA status is strongly related to GA, and that those babies born the earliest are at the greatest risk of LCPUFA deficiency.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume100
DOIs
StatePublished - Sep 1 2015

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Docosahexaenoic Acids
Unsaturated Fatty Acids
Arachidonic Acid
Gestational Age
Premature Infants
Blood
Intravenous Fat Emulsions
Chemical analysis
Linear Models
Linear regression
Association reactions
Fetus
Mothers
Pregnancy

Keywords

  • Arachidonic acid
  • Docosahexaenoic acid
  • Essential fatty acids
  • Long chain polyunsaturated acids
  • Neonatal nutrition
  • Prematurity

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

What is the relationship between gestational age and docosahexaenoic acid (DHA) and arachidonic acid (ARA) levels? / Baack, Michelle; Puumala, Susan E.; Messier, Stephen E.; Pritchett, Deborah K.; Harris, William S.

In: Prostaglandins Leukotrienes and Essential Fatty Acids, Vol. 100, 01.09.2015, p. 5-11.

Research output: Contribution to journalArticle

Baack, Michelle ; Puumala, Susan E. ; Messier, Stephen E. ; Pritchett, Deborah K. ; Harris, William S. / What is the relationship between gestational age and docosahexaenoic acid (DHA) and arachidonic acid (ARA) levels?. In: Prostaglandins Leukotrienes and Essential Fatty Acids. 2015 ; Vol. 100. pp. 5-11.
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