What do we know about adenovirus in renal transplantation?

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Adenoviruses are common pathogens that have the potential to cause opportunistic infections with significant morbidity and mortality in immunocompromised hosts. The significance of adenoviral infection and disease is incompletely known in the setting of kidney transplantation. Reported adenovirus infections in renal transplant recipients have typically manifested as hemorrhagic cystitis and tubulointerstitial nephritis, less severe diseases than often seen in other solid organ transplant recipients (i.e. pneumonia, hepatitis and enteritis). The prevalent adenovirus subgroups associated with cystitis and nephritis are B1 and B2 with the serotypes 7, 11, 34, 35. However, disseminated or severe adenovirus infections, including fatal cases, have been described in renal transplant recipients. There is uncertainty regarding monitoring of and treatment of this virus. Although not supported by randomized clinical trials, cidofovir is used for the treatment of adenovirus disease not responding to reduction of immunosuppression.

Original languageEnglish (US)
Pages (from-to)2003-2010
Number of pages8
JournalNephrology Dialysis Transplantation
Volume28
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

Adenoviridae
Kidney Transplantation
Adenoviridae Infections
Cystitis
Kidney
Interstitial Nephritis
Enteritis
Nephritis
Opportunistic Infections
Immunocompromised Host
Immunosuppression
Hepatitis
Uncertainty
Pneumonia
Randomized Controlled Trials
Viruses
Morbidity
Transplants
Mortality
Therapeutics

Keywords

  • Adenovirus
  • Disease
  • Infection
  • Kidney transplantation
  • Renal transplantation

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

What do we know about adenovirus in renal transplantation? / Florescu, Marius C; Miles, Clifford D; Florescu, Diana F.

In: Nephrology Dialysis Transplantation, Vol. 28, No. 8, 01.08.2013, p. 2003-2010.

Research output: Contribution to journalArticle

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