Volumetric localization of epileptic activity using wavelet-based synthetic aperture magnetometry

Jing Xiang, Yingying Wang, Zheng Xiao, Christina Balioussis, Hongmei Zhu, Stephanie Holowka, Roy Sharma, Amrita Hunjan, Hiroshi Otsubo, Sylvester Chuang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

To go beyond using magnetoencephalography (MEG) for visual identification of epileptic spikes, this study was to quantitatively estimate epileptic spectral power and volumetrically localize the neuromagnetic activity associated with epilepsy. MEG data were recorded from 16 patients with epilepsy using a whole-cortex MEG system. Focal increases of spectral power were identified using wavelet; the three-dimensional neuromagnetic distributions of the focal increases of spectral power were estimated using synthetic aperture magnetometry (SAM). SAM images and dipoles pointed to a same area in 12 patients (75% 12/16), SAM revealed focal epileptic activity but dipole modelling failed in 2 patients (12.5%, 2/16), and SAM detected more epileptic foci than dipole modelling did in 2 patients (12.5%, 2/16). Interestingly, spectrogram revealed focal increases of spectral power just before magnetic spikes; and SAM peaks were close to the dipoles of the initial portion of the spikes. The results suggest that wavelet-based SAM analysis has the potential to localize the onset of epileptic seizures, and seems superior to dipole modelling for estimation of multiple epileptic foci. In comparison to the conventional visual identification of spike, wavelet-based SAM analysis is objective and quantitative. Thus, wavelet-based SAM analysis has the potential to be extremely useful for clinical management of epilepsy.

Original languageEnglish (US)
Pages (from-to)697-700
Number of pages4
JournalInternational Congress Series
Volume1300
DOIs
StatePublished - Jun 1 2007

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Magnetometry
Magnetoencephalography
Epilepsy

Keywords

  • Epilepsy
  • High frequency
  • Magnetoencephalography
  • Neuromagnetic signals
  • Synthetic aperture magnetometry (SAM)
  • Wavelet

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Volumetric localization of epileptic activity using wavelet-based synthetic aperture magnetometry. / Xiang, Jing; Wang, Yingying; Xiao, Zheng; Balioussis, Christina; Zhu, Hongmei; Holowka, Stephanie; Sharma, Roy; Hunjan, Amrita; Otsubo, Hiroshi; Chuang, Sylvester.

In: International Congress Series, Vol. 1300, 01.06.2007, p. 697-700.

Research output: Contribution to journalArticle

Xiang, J, Wang, Y, Xiao, Z, Balioussis, C, Zhu, H, Holowka, S, Sharma, R, Hunjan, A, Otsubo, H & Chuang, S 2007, 'Volumetric localization of epileptic activity using wavelet-based synthetic aperture magnetometry', International Congress Series, vol. 1300, pp. 697-700. https://doi.org/10.1016/j.ics.2007.03.003
Xiang, Jing ; Wang, Yingying ; Xiao, Zheng ; Balioussis, Christina ; Zhu, Hongmei ; Holowka, Stephanie ; Sharma, Roy ; Hunjan, Amrita ; Otsubo, Hiroshi ; Chuang, Sylvester. / Volumetric localization of epileptic activity using wavelet-based synthetic aperture magnetometry. In: International Congress Series. 2007 ; Vol. 1300. pp. 697-700.
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