Volume expansion attenuates baroreflex sensitivity in the conscious nonhuman primate

K. G. Cornish, M. W. Barazanji, T. Yong, J. P. Gilmore

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We examined the effect of intravascular volume expansion (VE) on the arterial baroreflex control of pulse rate (PR) in conscious, chronically instrumented monkeys tethered in their cages. A total of five monkeys was studied after surgical implantation of catheters in the descending aorta, the left atrium, and the internal jugular vein. Mean arterial blood pressure (MABP)-PR stimulus response curves were constructed by decreasing and increasing blood pressure with nitroprusside and phenylephrine, respectively. The data were analyzed with a regression analysis that generated a sigmoid curve and the maximum sensitivity (slope) of the curve. The data were obtained before and after VE with an isotonic isoncotic dextran solution equal to 20% of the estimated blood volume. After VE, the MABP-PR curve shifted to the right at the high blood pressures, and there was a significant decrease in the maximum sensitivity from 5.65 ± 1.44 for control to 2.14 ± 0.63 after VE (P < 0.05). We concluded that VE attenuates the baroreflex control of heart rate in the conscious nonhuman primate.

Original languageEnglish (US)
Pages (from-to)26/3
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume257
Issue number3
StatePublished - Jan 1 1989

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Baroreflex
Primates
Arterial Pressure
Heart Rate
Haplorhini
Jugular Veins
Nitroprusside
Phenylephrine
Sigmoid Colon
Dextrans
Blood Volume
Heart Atria
Thoracic Aorta
Catheters
Regression Analysis
Blood Pressure
Hypertension

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Volume expansion attenuates baroreflex sensitivity in the conscious nonhuman primate. / Cornish, K. G.; Barazanji, M. W.; Yong, T.; Gilmore, J. P.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 257, No. 3, 01.01.1989, p. 26/3.

Research output: Contribution to journalArticle

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