Voltage-gated potassium channels in human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorders

James Keblesh, Dehui Hu, Huangui Xiong

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Human immunodeficiency virus type-1 (HIV-1)-associated dementia (HAD), a severe form of HIV-associated neurocognitive disorders (HAND), describes the cognitive impairments and behavioral disturbances which afflict many HIV-infected individuals. Although the precise mechanism leading to HAD is incompletely understood, it is commonly accepted its progression involves a critical mass of infected and activated mononuclear phagocytes (brain perivascular macrophages and microglia) releasing immune and viral products in the brain. These cellular and viral products induce neuronal dysfunction and injury via various signaling pathways. Emerging evidence indicates voltage-gated potassium (Kv) channels, key regulators of cell excitability and animal behavior (learning and memory), are involved in the pathogenesis of HAD/HAND. Here we survey the literature and find that HAD-related alterations in cellular and viral products can increase neuronal Kv channel activity, leading to neuronal dysfunction and cognitive deficits. Thus, neuronal Kv channels may be a new target in the effort to develop therapies for HAD and perhaps other inflammatory neurodegenerative disorders.

Original languageEnglish (US)
Pages (from-to)60-70
Number of pages11
JournalJournal of Neuroimmune Pharmacology
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2009

Fingerprint

Voltage-Gated Potassium Channels
HIV-1
Dementia
HIV
AIDS Dementia Complex
Animal Behavior
Brain
Microglia
Phagocytes
Neurodegenerative Diseases
Macrophages
Neurocognitive Disorders
Learning
Wounds and Injuries

Keywords

  • Cytokines
  • HIV-1-associated dementia
  • Learning and memory
  • Long-term potentiation
  • Mononuclear phagocytes
  • Voltage-gated K channels

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Voltage-gated potassium channels in human immunodeficiency virus type-1 (HIV-1)-associated neurocognitive disorders. / Keblesh, James; Hu, Dehui; Xiong, Huangui.

In: Journal of Neuroimmune Pharmacology, Vol. 4, No. 1, 01.03.2009, p. 60-70.

Research output: Contribution to journalReview article

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