Voltage-gated potassium channel modulation of neurotoxic activity in human immunodeficiency virus type-1(HIV-1)-infected macrophages

Elizabeth Irvine, James Keblesh, Jianuo Liu, Huangui Xiong

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Macrophages play an important role in brain immune and inflammatory responses. They are also critical cells in mediating the pathology of neurodegenerative disorders such as HIV-associated dementia. This is largely through their capacity to secrete a variety of bioactive molecules such as cytokines, leading to neuronal dysfunction and/or death. Accumulating evidence indicates that voltage-gated potassium (Kv) channels play a pivotal role in the modulation of macrophage proliferation, activation, and secretion. Blockade of Kv channels by specific antagonists decreases macrophage cytokine production and ameliorates macrophage-associated neuronal injury. These results suggest that Kv channels might become a potential target for the development of new therapeutic strategies for chronic inflammatory diseases.

Original languageEnglish (US)
Pages (from-to)265-269
Number of pages5
JournalJournal of Neuroimmune Pharmacology
Volume2
Issue number3
DOIs
Publication statusPublished - Sep 1 2007

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Keywords

  • 4-amonopyridine
  • HIV-1-associated dementia
  • Macrophage
  • Neurotoxin
  • Voltage-gated potassium channel

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

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