Vitamin deficits in severe alcoholic fatty liver of man calculated from multiple reference units

Oscar Frank, Anita Luisada-Opper, Michael Floyd Sorrell, Allan D. Thomson, Herman Baker

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Liver tissue levels of thiamine, pantothenate, biotin, vitamin B 12 , total folates, nicotinate, and vitamin B 6 were determined in biopsy and autopsy specimens from 69 patients with normal liver and 44 patients with severe fatty liver. These results define normal liver tissue B-complex vitamin levels in man and demonstrate a significant reduction of all the vitamins when the liver is severely infiltrated with fat. When vitamin levels in liver were related to dry weight, total fats, total nitrogen, and DNA-phosphorus as reference bases, vitamin titers in order of decreasing magnitude in normal livers were nicotinate, pantothenate, B 6 , thiamine, N 5 -methyltetrahydrofolates, other tetrahydrofolates, B 12 , and biotin. In the severe fatty liver pantothenate was higher than nicotinate and other tetrahydrofolates were higher than N 5 -methyltetrahydrofolates. Biotin was markedly decreased in the severe fatty liver when dry weight, total fat, total nitrogen, and DNA-phosphorus were each used as reference base; however, the thiamine and N 5 -methyltetrahydrofolate pattern varied if dry weight alone was used as reference base. Total liver fat compared favorably with total nitrogen and DNA-phosphorus as a reference base. It showed close agreement with, on one hand, tissue vitamin decreases and on the other hand, with histologically demonstrable fat.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalExperimental and Molecular Pathology
Volume15
Issue number2
DOIs
StatePublished - Jan 1 1971

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Alcoholic Fatty Liver
Vitamins
Liver
Fats
Tetrahydrofolates
Niacin
Thiamine
Fatty Liver
Biotin
Phosphorus
Nitrogen
Weights and Measures
DNA
Tissue
Vitamin B Complex
Vitamin B 6
Vitamin B 12
Folic Acid
Autopsy
Biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Vitamin deficits in severe alcoholic fatty liver of man calculated from multiple reference units. / Frank, Oscar; Luisada-Opper, Anita; Sorrell, Michael Floyd; Thomson, Allan D.; Baker, Herman.

In: Experimental and Molecular Pathology, Vol. 15, No. 2, 01.01.1971, p. 191-197.

Research output: Contribution to journalArticle

Frank, Oscar ; Luisada-Opper, Anita ; Sorrell, Michael Floyd ; Thomson, Allan D. ; Baker, Herman. / Vitamin deficits in severe alcoholic fatty liver of man calculated from multiple reference units. In: Experimental and Molecular Pathology. 1971 ; Vol. 15, No. 2. pp. 191-197.
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