Abstract

Rationale Vitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP. Objective This is a pilot study of a portion of the subjects in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study designed to examine the relationship between vitamin D status, DBP, FEV1 and emphysema in COPD patients. Methods We measured serum 25(OH)D and DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker controls, non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, the subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT-defined emphysema, biomarkers and clinical data including CT-measured bone attenuation were assessed. Measurements 25(OH)D and DBP were measured using tandem mass spectroscopy and competitive enzyme-linked immunosorbent assay, respectively, Main result 25(OH)D was correlated with FEV1 (p = 0.01) and with severity of emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk (p = 0.02), bronchodilator response (p = 0.04), and Clara cell secretory protein (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured bone attenuation, however DBP was associated with bone attenuation in subjects with emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and DBP were inversely associated (p = 0.01). Conclusion This is the first study to demonstrate a relationship between emphysema and vitamin D. We also provide further evidence for a relationship between vitamin D and FEV1.

Original languageEnglish (US)
Pages (from-to)1578-1588
Number of pages11
JournalRespiratory Medicine
Volume107
Issue number10
DOIs
StatePublished - Oct 1 2013

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Vitamin D-Binding Protein
Emphysema
Vitamin D
Chronic Obstructive Pulmonary Disease
Carrier Proteins
Lung
Biomarkers
Bone and Bones
Uteroglobin
Bronchodilator Agents
Mass Spectrometry
Enzyme-Linked Immunosorbent Assay

Keywords

  • 25(OH)D
  • Emphysema
  • FEV1
  • Free vitamin D

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Vitamin D, vitamin D binding protein, lung function and structure in COPD. / Berg, Isaac; Hanson, Corrine K; Sayles, Harlan; Romberger, Debra; Nelson, Amy; Meza, Jane L; Miller, Bruce; Wouters, Emiel F M; Macnee, William; Rutten, E. P A; Romme, Elisabeth A P M; Vestbo, Jørgen; Edwards, Lisa; Rennard, Stephen.

In: Respiratory Medicine, Vol. 107, No. 10, 01.10.2013, p. 1578-1588.

Research output: Contribution to journalArticle

Berg, I, Hanson, CK, Sayles, H, Romberger, D, Nelson, A, Meza, JL, Miller, B, Wouters, EFM, Macnee, W, Rutten, EPA, Romme, EAPM, Vestbo, J, Edwards, L & Rennard, S 2013, 'Vitamin D, vitamin D binding protein, lung function and structure in COPD', Respiratory Medicine, vol. 107, no. 10, pp. 1578-1588. https://doi.org/10.1016/j.rmed.2013.05.010
Berg, Isaac ; Hanson, Corrine K ; Sayles, Harlan ; Romberger, Debra ; Nelson, Amy ; Meza, Jane L ; Miller, Bruce ; Wouters, Emiel F M ; Macnee, William ; Rutten, E. P A ; Romme, Elisabeth A P M ; Vestbo, Jørgen ; Edwards, Lisa ; Rennard, Stephen. / Vitamin D, vitamin D binding protein, lung function and structure in COPD. In: Respiratory Medicine. 2013 ; Vol. 107, No. 10. pp. 1578-1588.
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abstract = "Rationale Vitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP. Objective This is a pilot study of a portion of the subjects in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study designed to examine the relationship between vitamin D status, DBP, FEV1 and emphysema in COPD patients. Methods We measured serum 25(OH)D and DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker controls, non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, the subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT-defined emphysema, biomarkers and clinical data including CT-measured bone attenuation were assessed. Measurements 25(OH)D and DBP were measured using tandem mass spectroscopy and competitive enzyme-linked immunosorbent assay, respectively, Main result 25(OH)D was correlated with FEV1 (p = 0.01) and with severity of emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk (p = 0.02), bronchodilator response (p = 0.04), and Clara cell secretory protein (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured bone attenuation, however DBP was associated with bone attenuation in subjects with emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and DBP were inversely associated (p = 0.01). Conclusion This is the first study to demonstrate a relationship between emphysema and vitamin D. We also provide further evidence for a relationship between vitamin D and FEV1.",
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T1 - Vitamin D, vitamin D binding protein, lung function and structure in COPD

AU - Berg, Isaac

AU - Hanson, Corrine K

AU - Sayles, Harlan

AU - Romberger, Debra

AU - Nelson, Amy

AU - Meza, Jane L

AU - Miller, Bruce

AU - Wouters, Emiel F M

AU - Macnee, William

AU - Rutten, E. P A

AU - Romme, Elisabeth A P M

AU - Vestbo, Jørgen

AU - Edwards, Lisa

AU - Rennard, Stephen

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Rationale Vitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP. Objective This is a pilot study of a portion of the subjects in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study designed to examine the relationship between vitamin D status, DBP, FEV1 and emphysema in COPD patients. Methods We measured serum 25(OH)D and DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker controls, non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, the subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT-defined emphysema, biomarkers and clinical data including CT-measured bone attenuation were assessed. Measurements 25(OH)D and DBP were measured using tandem mass spectroscopy and competitive enzyme-linked immunosorbent assay, respectively, Main result 25(OH)D was correlated with FEV1 (p = 0.01) and with severity of emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk (p = 0.02), bronchodilator response (p = 0.04), and Clara cell secretory protein (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured bone attenuation, however DBP was associated with bone attenuation in subjects with emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and DBP were inversely associated (p = 0.01). Conclusion This is the first study to demonstrate a relationship between emphysema and vitamin D. We also provide further evidence for a relationship between vitamin D and FEV1.

AB - Rationale Vitamin D and vitamin D binding protein (DBP) have been associated with COPD and FEV1. There are limited data regarding emphysema and vitamin D and DBP. Objective This is a pilot study of a portion of the subjects in the Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) study designed to examine the relationship between vitamin D status, DBP, FEV1 and emphysema in COPD patients. Methods We measured serum 25(OH)D and DBP in 498 ECLIPSE subjects. Subjects were distributed amongst smoker controls, non-smoker controls, and GOLD stages 2, 3 and 4. Within each GOLD stage, the subjects were equally divided amongst high and low emphysema burden. The associations between 25(OH)D, DBP, and free vitamin D with FEV1, CT-defined emphysema, biomarkers and clinical data including CT-measured bone attenuation were assessed. Measurements 25(OH)D and DBP were measured using tandem mass spectroscopy and competitive enzyme-linked immunosorbent assay, respectively, Main result 25(OH)D was correlated with FEV1 (p = 0.01) and with severity of emphysema (p < 0.01). 25(OH)D was also associated with six-minute walk (p = 0.02), bronchodilator response (p = 0.04), and Clara cell secretory protein (CC-16) (p = 0.01). 25(OH)D levels were not associated with CT-measured bone attenuation, however DBP was associated with bone attenuation in subjects with emphysema. DBP was not associated with FEV1 or emphysema. 25(OH)D and DBP were inversely associated (p = 0.01). Conclusion This is the first study to demonstrate a relationship between emphysema and vitamin D. We also provide further evidence for a relationship between vitamin D and FEV1.

KW - 25(OH)D

KW - Emphysema

KW - FEV1

KW - Free vitamin D

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