Vitamin D Status and Associations With Risk Factors for Cardiovascular Disease and Diabetes in Children Enrolled in a Medical Weight Management Program

Corrine K Hanson, Ann L Anderson Berry, Shelby Hoskins, Elizabeth Lyden, Laura Diane Bilek, Tamara Dolphens, Krystal Hartmann, Mary Jane Hawkins, Cristina Fernandez

Research output: Contribution to journalArticle

Abstract

Background. Studies of vitamin D status have linked low 25(OH)D levels with biomarkers of cardiovascular disease and diabetes. Obese children and adolescents are at greater risk of vitamin D deficiency as vitamin D is thought to be sequestered in adipose tissue. The objective of this analysis was to examine the associations between 25(OH)D status and risk factors for cardiovascular disease and diabetes in a population of overweight and obese children enrolled in a medical management program. Materials and Methods. A retrospective chart review was conducted of 161 children enrolled in a medical weight management program. Pearson correlation coefficient were used to evaluate associations of biochemical measurements and 25(OH)D status. Multiple regression was used to evaluate 25(OH)D levels as a predictor of risk factors for cardiovascular disease and diabetes. Results. The mean body mass index (BMI) of the population was 34 kg/m2, mean 25(OH)D levels were 21.8 ng/mL. White subjects had significantly higher 25(OH)D levels than non-whites (24.1 vs 19.2, P =.004). 25(OH)D levels were inversely related to BMI (r = −0.21, P =.03) and waist circumference (r = −0.23, P =.02). After adjustment for BMI and age, 25(OH)D was significantly associated with total cholesterol (P =.0003), triglycerides (P =.0007), homeostasis model assessment–estimated insulin resistance (HOMA-IR; P =.005) and insulin (P =.0003). The decrease in each unit of cholesterol, triglycerides, and insulin for each 1% increase in log transformed 25(OH)D were 0.3, 0.65, and 0.1,1 respectively. Each 1% increase in 25(OH)D levels was associated with a 0.05% decrease in HOMA-IR values. Conclusion. Vitamin D status was associated with risk factors for diabetes and cardiovascular disease in an obese pediatric population.

Original languageEnglish (US)
Pages (from-to)233-239
Number of pages7
JournalInfant, Child, and Adolescent Nutrition
Volume6
Issue number4
DOIs
Publication statusPublished - Aug 13 2014

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Keywords

  • adolescents
  • cardiovascular disease
  • children
  • diabetes
  • obese
  • overweight
  • vitamin D

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Food Science
  • Nutrition and Dietetics

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