Viruses infecting marine picoplancton encode functional potassium ion channels

Fenja Siotto, Corinna Martin, Oliver Rauh, James L Van Etten, Indra Schroeder, Anna Moroni, Gerhard Thiel

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Phycodnaviruses are dsDNA viruses, which infect algae. Their large genomes encode many gene products, like small K+ channels, with homologs in prokaryotes and eukaryotes. Screening for K+ channels revealed their abundance in viruses from fresh-water habitats. Recent sequencing of viruses from marine algae or from salt water in Antarctica revealed sequences with the predicted characteristics of K+ channels but with some unexpected features. Two genes encode either 78 or 79 amino acid proteins, which are the smallest known K+ channels. Also of interest is an unusual sequence in the canonical α-helixes in K+ channels. Structural prediction algorithms indicate that the new channels have the conserved α-helix folds but the algorithms failed to identify the expected transmembrane domains flanking the K+ channel pores. In spite of these unexpected properties electophysiological studies confirmed that the new proteins are functional K+ channels.

Original languageEnglish (US)
Pages (from-to)103-111
Number of pages9
JournalVirology
Volume466-467
DOIs
StatePublished - Oct 1 2014

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Potassium Channels
Viruses
Eukaryota
Fresh Water
Genes
Ecosystem
Salts
Genome
Amino Acids
Water
Proteins

Keywords

  • Algal viruses
  • Chlorella viruses
  • K channel evolution
  • Kcv
  • Virus evolution

ASJC Scopus subject areas

  • Virology

Cite this

Siotto, F., Martin, C., Rauh, O., Van Etten, J. L., Schroeder, I., Moroni, A., & Thiel, G. (2014). Viruses infecting marine picoplancton encode functional potassium ion channels. Virology, 466-467, 103-111. https://doi.org/10.1016/j.virol.2014.05.002

Viruses infecting marine picoplancton encode functional potassium ion channels. / Siotto, Fenja; Martin, Corinna; Rauh, Oliver; Van Etten, James L; Schroeder, Indra; Moroni, Anna; Thiel, Gerhard.

In: Virology, Vol. 466-467, 01.10.2014, p. 103-111.

Research output: Contribution to journalArticle

Siotto, F, Martin, C, Rauh, O, Van Etten, JL, Schroeder, I, Moroni, A & Thiel, G 2014, 'Viruses infecting marine picoplancton encode functional potassium ion channels', Virology, vol. 466-467, pp. 103-111. https://doi.org/10.1016/j.virol.2014.05.002
Siotto, Fenja ; Martin, Corinna ; Rauh, Oliver ; Van Etten, James L ; Schroeder, Indra ; Moroni, Anna ; Thiel, Gerhard. / Viruses infecting marine picoplancton encode functional potassium ion channels. In: Virology. 2014 ; Vol. 466-467. pp. 103-111.
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