Virus-host mucosal interactions during early SIV rectal transmission

Wuxun Lu, Fangrui Ma, Alexander Churbanov, Yanmin Wan, Yue Li, Guobin Kang, Zhe Yuan, Dong Wang, Chi Zhang, Jianqing Xu, Mark Lewis, Qingsheng Li

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

To deepen our understanding of early rectal transmission of HIV-1, we studied virus-host interactions in the rectal mucosa using simian immunodeficiency virus (SIV)-Indian rhesus macaque model and mRNA deep sequencing. We found that rectal mucosa actively responded to SIV as early as 3 days post-rectal inoculation (dpi) and mobilized more robust responses at 6 and 10. dpi. Our results suggest that the failure of the host to contain virus replication at the portal of entry is attributable to both a high-level expression of lymphocyte chemoattractant, proinflammatory and immune activation genes, which can recruit and activate viral susceptible target cells into mucosa; and a high-level expression of SIV accessory genes, which are known to be able to counter and evade host restriction factors and innate immune responses. This study provides new insights into the mechanism of rectal transmission.

Original languageEnglish (US)
Pages (from-to)406-414
Number of pages9
JournalVirology
Volume464-465
Issue number1
DOIs
Publication statusPublished - Sep 2014

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Keywords

  • Mucosal response
  • Rectal transmission
  • Simian immunodeficiency virus (SIV)
  • mRNA-seq

ASJC Scopus subject areas

  • Virology

Cite this

Lu, W., Ma, F., Churbanov, A., Wan, Y., Li, Y., Kang, G., ... Li, Q. (2014). Virus-host mucosal interactions during early SIV rectal transmission. Virology, 464-465(1), 406-414. https://doi.org/10.1016/j.virol.2014.07.010