Vincristine and dactinomycin in infantile myofibromatosis with a review of treatment options

Meaghann S. Weaver, Fariba Navid, Alison Huppmann, Holly Meany, Anne Angiolillo

Research output: Contribution to journalReview article

9 Scopus citations


Although solitary presentations of infantile myofibromatosis tend toward spontaneous regression, multicentric forms fare worse. Previous case reports have depicted observation, surgical resection, and systemic therapies as treatment options. This paper reports well-tolerated, successful outcomes in a series of patients with high-risk infantile myofibromatosis in need of life-sustaining interventions treated with a combination of vincristine and dactinomycin. The clinical presentation, pathology, and radiographic findings are described.

Original languageEnglish (US)
Pages (from-to)237-241
Number of pages5
JournalJournal of Pediatric Hematology/Oncology
Issue number3
StatePublished - Apr 7 2015



  • Infantile myofibromatosis
  • dactinomycin
  • vincristine

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this