Vimentin expression in human squamous carcinoma cells: Relationship with phenotypic changes and cadherin-based cell adhesion

Shahidul Islam, Jae Beom Kim, Jill Trendel, Margaret J. Wheelock, Keith R. Johnson

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Phenotypic changes resembling an epithelial-to-mesenchymal transition often occur as epithelial cells become tumorigenic. Two proteins that have been implicated in this process are vimentin and N-cadherin. In this study, we sought to establish a link between expression of vimentin and N-cadherin as oral squamous epithelial cells undergo a morphologic change resembling an epithelial-to-mesenchymal transition. We found that N-cadherin and vimentin did not influence the expression of one another. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalJournal of Cellular Biochemistry
Volume78
Issue number1
DOIs
StatePublished - Jun 22 2000

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Keywords

  • Epithelial to mesenchymal transition
  • N-cadherin
  • Squamous cell carcinoma
  • Vimentin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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