Vestibular evoked potentials in response to direct unilateral mechanical stimulation

Franklin S. Coale, Edward J Walsh, JoAnn D McGee, Horst R. Konrad

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Evoked potentials produced by direct unilateral mechanical stimuiation of the cannulated horizontal semicircular canal were investigated parametrically in anesthetized adult cats (40 mg/kg pentobarbital). Stimuli were fluid pressure pulses in a closed hydraulic system (no net flow), which was coupled to the lateral semicircular canal near the ampulla. Hydraulic waveform output and fluid pressure was monitored In situ via a parallel hydraulic circuit during experiments. Maximum fluid displacement at the level of the horizontal canal was 0.025 microliters. The intensity, duration, and presentation rate of the stimulus were varied during experiments. Field potentials were recorded differentially using subdermal electrodes, with the active lead in the region of the mastoid referenced to a distant nasal site. A total of 256 trials was accumulated for each run using an averaging computer. Evoked responses were physiologically vulnerable and reproducible, with little variance among animals. Response amplitude Increased monotonically until saturation was noted and responses followed the temporal structure of the pressure wave. Polarity reversal with differir electrode placement suggests that the generator site lies within the mastoid. Buhner, intense broadband acoustic stimuli and eighth nerve sectioning did not affect the vestibular evoked potentials, but could be shown to abolish the auditory evoked potentials. Results of these experiments support the notion that vestibular evoked potentials are related to the first derivative of the pressure pulse waveforms. Future experiments will be directed toward the assessment of vestibular physiology and pharmacology with this evoked response method.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalOtolaryngology–Head and Neck Surgery
Volume100
Issue number3
DOIs
StatePublished - Jan 1 1989

Fingerprint

Evoked Potentials
Semicircular Canals
Mastoid
Electrodes
Blood Pressure
Pressure
Auditory Evoked Potentials
Pentobarbital
Nose
Acoustics
Cats
Pharmacology

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Cite this

Vestibular evoked potentials in response to direct unilateral mechanical stimulation. / Coale, Franklin S.; Walsh, Edward J; McGee, JoAnn D; Konrad, Horst R.

In: Otolaryngology–Head and Neck Surgery, Vol. 100, No. 3, 01.01.1989, p. 177-186.

Research output: Contribution to journalArticle

Coale, Franklin S. ; Walsh, Edward J ; McGee, JoAnn D ; Konrad, Horst R. / Vestibular evoked potentials in response to direct unilateral mechanical stimulation. In: Otolaryngology–Head and Neck Surgery. 1989 ; Vol. 100, No. 3. pp. 177-186.
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