Ventricular shunt infections: Immunopathogenesis and clinical management

Yenis Gutierrez-Murgas, Jessica Snowden

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Ventricular shunts are the most common neurosurgical procedure performed in the United States. This hydrocephalus treatment is often complicated by infection of the device with biofilm-forming bacteria. In this review, we discuss the pathogenesis of shunt infection, as well as the implications of the biofilm formation on treatment and prevention of these infections. Many questions remain, including the contribution of glia and the impact of inflammation on developmental outcomes following infection. Immune responses within the CNS must be carefully regulated to contain infection while minimizing bystander damage; further study is needed to design optimal treatment strategies for these patients.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalJournal of Neuroimmunology
Volume276
Issue number1-2
DOIs
StatePublished - Nov 15 2014

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Infection
Biofilms
Neurosurgical Procedures
Hydrocephalus
Neuroglia
Therapeutics
Inflammation
Bacteria
Equipment and Supplies

Keywords

  • Biofilm
  • Catheter
  • Central nervous system
  • Shunt infection

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Ventricular shunt infections : Immunopathogenesis and clinical management. / Gutierrez-Murgas, Yenis; Snowden, Jessica.

In: Journal of Neuroimmunology, Vol. 276, No. 1-2, 15.11.2014, p. 1-8.

Research output: Contribution to journalReview article

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