Vasoregulation at the molecular level: A role for the β1 subunit of the calcium-activated potassium (BK) channel

Andrew J. Patterson, Jenifer Henrie-Olson, Robert Brenner

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

Essential hypertension is among the most common and most costly medical conditions in the United States. Multiple defects in the kidneys, the vasculature, and the neuro-endocrine system may contribute to the development of this disorder. Within the past decade investigators have identified several molecular components of the vasculature that control tone and influence blood pressure. For example, the large conductance BK type calcium-activated potassium channel has recently been shown to play an important role in maintaining the dynamic equilibrium between vasoconstriction and vasodilation of vascular smooth muscle. Activation of vascular smooth muscle BK channels leads to hyperpolarization of the cell membrane, which causes deactivation of voltage-dependent calcium channels and vasodilation. In this review, we will summarize recently published data focusing on the role of the BK channel's accessory β1 subunit as well as other modulators of BK channel activation that influence vascular tone and blood pressure.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume12
Issue number2
DOIs
StatePublished - Feb 26 2002

Fingerprint

Large-Conductance Calcium-Activated Potassium Channels
Calcium-Activated Potassium Channels
Vascular Smooth Muscle
Vasodilation
Blood Pressure
Endocrine System
Calcium Channels
Vasoconstriction
Blood Vessels
Research Personnel
Cell Membrane
Kidney

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Vasoregulation at the molecular level : A role for the β1 subunit of the calcium-activated potassium (BK) channel. / Patterson, Andrew J.; Henrie-Olson, Jenifer; Brenner, Robert.

In: Trends in Cardiovascular Medicine, Vol. 12, No. 2, 26.02.2002, p. 78-82.

Research output: Contribution to journalReview article

Patterson, Andrew J. ; Henrie-Olson, Jenifer ; Brenner, Robert. / Vasoregulation at the molecular level : A role for the β1 subunit of the calcium-activated potassium (BK) channel. In: Trends in Cardiovascular Medicine. 2002 ; Vol. 12, No. 2. pp. 78-82.
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