Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with type 1 diabetes mellitus: Relation to glycaemic control and microvascular complications

F. Chiarelli, A. Spagnoli, F. Basciani, S. Tumini, A. Mezzetti, F. Cipollone, F. Cuccurullo, G. Morgese, A. Verrotti

Research output: Contribution to journalArticle

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Abstract

Aims To evaluate serum levels of vascular endothelial growth factor (VEGF) in a large group of children, adolescents and young adults with Type 1 diabetes mellitus to investigate whether increased VEGF concentrations are associated with long-term glycaemic control and microvascular complications. Methods: The study involved 196 patients with Type 1 diabetes mellitus (age range 2-24 years, onset of diabetes before the age of 12 years, duration of disease longer than 2 years), without clinical and laboratory signs of microvascular complications; they were divided into three groups (group 1 - n = 37, age < 6 years; group 2 - n = 71, age 6-12 years; group 3 - n = 88-age > 12 years). Fifty-three adolescents and young adults (age 16.1-29.7) with different grades of diabetic retinopathy and microalbuminuria were also selected (group 4). A total of 223 healthy controls were matched for age and sex with each group of patients with diabetes mellitus. Results: VEGF serum levels were significantly increased in pre-school and prepubertal children with diabetes as well as in pubertal patients compared to controls. VEGF concentrations were markedly increased in adolescents and young adults with microvascular complications compared with both healthy controls and diabetic patients without retinopathy or nephropathy. Multivariate analysis showed that elevation of VEGF in serum was an independent correlate of complications. One-year mean HbA(1c) values were significantly correlated with VEGF concentrations (r = 0.372; P < 0.01). Children with HbA(1c) levels greater than 10% had significantly higher VEGF concentrations when compared with matched patients whose HbA(1c) levels were lower than 10%. In poorly controlled diabetic children (HbA(1c) > 10%), long-term (2 years) improvement of glycaemic control (aiming at HbA(1c) < 7%) resulted in a significant reduction of VEGF levels. Conclusions: VEGF serum concentrations are increased in prepubertal and pubertal children with diabetes. Glycaemic control influences VEGF serum levels. Severity of microvascular complications is associated with marked increase of VEGF concentrations in the serum of these patients.

Original languageEnglish (US)
Pages (from-to)650-656
Number of pages7
JournalDiabetic Medicine
Volume17
Issue number9
DOIs
StatePublished - Nov 1 2000

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Type 1 Diabetes Mellitus
Vascular Endothelial Growth Factor A
Young Adult
Serum
Diabetic Retinopathy
Diabetes Mellitus
Multivariate Analysis

Keywords

  • Childhood
  • Diabetic nephropathy
  • Diabetic retinopathy
  • Glycaemic control
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with type 1 diabetes mellitus : Relation to glycaemic control and microvascular complications. / Chiarelli, F.; Spagnoli, A.; Basciani, F.; Tumini, S.; Mezzetti, A.; Cipollone, F.; Cuccurullo, F.; Morgese, G.; Verrotti, A.

In: Diabetic Medicine, Vol. 17, No. 9, 01.11.2000, p. 650-656.

Research output: Contribution to journalArticle

Chiarelli, F. ; Spagnoli, A. ; Basciani, F. ; Tumini, S. ; Mezzetti, A. ; Cipollone, F. ; Cuccurullo, F. ; Morgese, G. ; Verrotti, A. / Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with type 1 diabetes mellitus : Relation to glycaemic control and microvascular complications. In: Diabetic Medicine. 2000 ; Vol. 17, No. 9. pp. 650-656.
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T1 - Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with type 1 diabetes mellitus

T2 - Relation to glycaemic control and microvascular complications

AU - Chiarelli, F.

AU - Spagnoli, A.

AU - Basciani, F.

AU - Tumini, S.

AU - Mezzetti, A.

AU - Cipollone, F.

AU - Cuccurullo, F.

AU - Morgese, G.

AU - Verrotti, A.

PY - 2000/11/1

Y1 - 2000/11/1

N2 - Aims To evaluate serum levels of vascular endothelial growth factor (VEGF) in a large group of children, adolescents and young adults with Type 1 diabetes mellitus to investigate whether increased VEGF concentrations are associated with long-term glycaemic control and microvascular complications. Methods: The study involved 196 patients with Type 1 diabetes mellitus (age range 2-24 years, onset of diabetes before the age of 12 years, duration of disease longer than 2 years), without clinical and laboratory signs of microvascular complications; they were divided into three groups (group 1 - n = 37, age < 6 years; group 2 - n = 71, age 6-12 years; group 3 - n = 88-age > 12 years). Fifty-three adolescents and young adults (age 16.1-29.7) with different grades of diabetic retinopathy and microalbuminuria were also selected (group 4). A total of 223 healthy controls were matched for age and sex with each group of patients with diabetes mellitus. Results: VEGF serum levels were significantly increased in pre-school and prepubertal children with diabetes as well as in pubertal patients compared to controls. VEGF concentrations were markedly increased in adolescents and young adults with microvascular complications compared with both healthy controls and diabetic patients without retinopathy or nephropathy. Multivariate analysis showed that elevation of VEGF in serum was an independent correlate of complications. One-year mean HbA(1c) values were significantly correlated with VEGF concentrations (r = 0.372; P < 0.01). Children with HbA(1c) levels greater than 10% had significantly higher VEGF concentrations when compared with matched patients whose HbA(1c) levels were lower than 10%. In poorly controlled diabetic children (HbA(1c) > 10%), long-term (2 years) improvement of glycaemic control (aiming at HbA(1c) < 7%) resulted in a significant reduction of VEGF levels. Conclusions: VEGF serum concentrations are increased in prepubertal and pubertal children with diabetes. Glycaemic control influences VEGF serum levels. Severity of microvascular complications is associated with marked increase of VEGF concentrations in the serum of these patients.

AB - Aims To evaluate serum levels of vascular endothelial growth factor (VEGF) in a large group of children, adolescents and young adults with Type 1 diabetes mellitus to investigate whether increased VEGF concentrations are associated with long-term glycaemic control and microvascular complications. Methods: The study involved 196 patients with Type 1 diabetes mellitus (age range 2-24 years, onset of diabetes before the age of 12 years, duration of disease longer than 2 years), without clinical and laboratory signs of microvascular complications; they were divided into three groups (group 1 - n = 37, age < 6 years; group 2 - n = 71, age 6-12 years; group 3 - n = 88-age > 12 years). Fifty-three adolescents and young adults (age 16.1-29.7) with different grades of diabetic retinopathy and microalbuminuria were also selected (group 4). A total of 223 healthy controls were matched for age and sex with each group of patients with diabetes mellitus. Results: VEGF serum levels were significantly increased in pre-school and prepubertal children with diabetes as well as in pubertal patients compared to controls. VEGF concentrations were markedly increased in adolescents and young adults with microvascular complications compared with both healthy controls and diabetic patients without retinopathy or nephropathy. Multivariate analysis showed that elevation of VEGF in serum was an independent correlate of complications. One-year mean HbA(1c) values were significantly correlated with VEGF concentrations (r = 0.372; P < 0.01). Children with HbA(1c) levels greater than 10% had significantly higher VEGF concentrations when compared with matched patients whose HbA(1c) levels were lower than 10%. In poorly controlled diabetic children (HbA(1c) > 10%), long-term (2 years) improvement of glycaemic control (aiming at HbA(1c) < 7%) resulted in a significant reduction of VEGF levels. Conclusions: VEGF serum concentrations are increased in prepubertal and pubertal children with diabetes. Glycaemic control influences VEGF serum levels. Severity of microvascular complications is associated with marked increase of VEGF concentrations in the serum of these patients.

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KW - Diabetic nephropathy

KW - Diabetic retinopathy

KW - Glycaemic control

KW - Vascular endothelial growth factor

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