Varicella-zoster virus infections. Biology, natural history, treatment, and prevention

S. E. Straus, J. M. Ostrove, G. Inchauspe, J. M. Felser, A. Freifeld, K. D. Croen, M. H. Sawyer

Research output: Contribution to journalArticle

299 Citations (Scopus)

Abstract

During the last 10 years, there have been major advances in the understanding of varicella-zoster virus and the diseases it causes. The molecular biology of the virus is being unraveled with the aid of new molecular technologies. Varicella, usually a benign manifestation of primary infection, and zoster, a result of reactivation of latent virus, can cause considerable morbidity in patients with immune impairment. Antiviral drugs, especially acyclovir, ameliorate severe infections but still have little role in the treatment of most normal patients with varicella or zoster. Varicella can be prevented when necessary by patient isolation and passive prophylaxis with varicella-zoster immune globulin. An experimental live vaccine also prevents varicella, but problems regarding its virulence for immunosuppressed patients and the durability of the protective response are still being addressed.

Original languageEnglish (US)
Pages (from-to)221-237
Number of pages17
JournalAnnals of internal medicine
Volume108
Issue number2
DOIs
StatePublished - Jan 1 1988

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Human Herpesvirus 3
Chickenpox
Virus Diseases
Natural History
Herpes Zoster
Patient Isolation
Viruses
Acyclovir
Therapeutics
Infection
Antiviral Agents
Virulence
Molecular Biology
Vaccines
Technology
Morbidity

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Straus, S. E., Ostrove, J. M., Inchauspe, G., Felser, J. M., Freifeld, A., Croen, K. D., & Sawyer, M. H. (1988). Varicella-zoster virus infections. Biology, natural history, treatment, and prevention. Annals of internal medicine, 108(2), 221-237. https://doi.org/10.7326/0003-4819-108-2-221

Varicella-zoster virus infections. Biology, natural history, treatment, and prevention. / Straus, S. E.; Ostrove, J. M.; Inchauspe, G.; Felser, J. M.; Freifeld, A.; Croen, K. D.; Sawyer, M. H.

In: Annals of internal medicine, Vol. 108, No. 2, 01.01.1988, p. 221-237.

Research output: Contribution to journalArticle

Straus, SE, Ostrove, JM, Inchauspe, G, Felser, JM, Freifeld, A, Croen, KD & Sawyer, MH 1988, 'Varicella-zoster virus infections. Biology, natural history, treatment, and prevention', Annals of internal medicine, vol. 108, no. 2, pp. 221-237. https://doi.org/10.7326/0003-4819-108-2-221
Straus, S. E. ; Ostrove, J. M. ; Inchauspe, G. ; Felser, J. M. ; Freifeld, A. ; Croen, K. D. ; Sawyer, M. H. / Varicella-zoster virus infections. Biology, natural history, treatment, and prevention. In: Annals of internal medicine. 1988 ; Vol. 108, No. 2. pp. 221-237.
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