Variation in toll-like receptor 4 and susceptibility to group a meningococcal meningitis in Gambian children

Angela Allen, Stephen K Obaro, Kalifa Bojang, Agnes A. Awomoyi, Brian M. Greenwood, Hilton Whittle, Giorgio Sirugo, Melanie J. Newport

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Meningitis is an important cause of childhood mortality in sub-Saharan Africa. A case-control study investigating the role of the Toll-like receptor 4 gene in host susceptibility to Group A Neisseria meningitidis meningitis was conducted in 524 Gambian children. There was no association between a functional Toll-like receptor 4 gene polymorphism and meningitis, suggesting that this variant is not a major determinant of disease in this population.

Original languageEnglish (US)
Pages (from-to)1018-1019
Number of pages2
JournalPediatric Infectious Disease Journal
Volume22
Issue number11
DOIs
StatePublished - Nov 1 2003

Fingerprint

Meningococcal Meningitis
Toll-Like Receptor 4
Meningitis
Neisseria meningitidis
Africa South of the Sahara
Genes
Case-Control Studies
Mortality
Population

Keywords

  • Epidemic
  • Genetic
  • Meningitis
  • Sub-Saharan Africa
  • Susceptibility
  • Toll-like receptor 4

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Variation in toll-like receptor 4 and susceptibility to group a meningococcal meningitis in Gambian children. / Allen, Angela; Obaro, Stephen K; Bojang, Kalifa; Awomoyi, Agnes A.; Greenwood, Brian M.; Whittle, Hilton; Sirugo, Giorgio; Newport, Melanie J.

In: Pediatric Infectious Disease Journal, Vol. 22, No. 11, 01.11.2003, p. 1018-1019.

Research output: Contribution to journalArticle

Allen, Angela ; Obaro, Stephen K ; Bojang, Kalifa ; Awomoyi, Agnes A. ; Greenwood, Brian M. ; Whittle, Hilton ; Sirugo, Giorgio ; Newport, Melanie J. / Variation in toll-like receptor 4 and susceptibility to group a meningococcal meningitis in Gambian children. In: Pediatric Infectious Disease Journal. 2003 ; Vol. 22, No. 11. pp. 1018-1019.
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