Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma

Edwin C. Douglass, Susan T. Rowe, Marc Valentine, David M. Parham, Roger Berkow, W. Paul Bowman, Harold M. Maurer

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Abstract

In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2; 13)‐positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.

Original languageEnglish (US)
Pages (from-to)480-482
Number of pages3
JournalGenes, Chromosomes and Cancer
Volume3
Issue number6
DOIs
Publication statusPublished - Nov 1991

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ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Douglass, E. C., Rowe, S. T., Valentine, M., Parham, D. M., Berkow, R., Paul Bowman, W., & Maurer, H. M. (1991). Variant Translocations of Chromosome 13 in Alveolar Rhabdomyosarcoma. Genes, Chromosomes and Cancer, 3(6), 480-482. https://doi.org/10.1002/gcc.2870030611