Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV

Vanessa Rivera-Amill, Richard J. Noel, Suheydi Orsini, Griselle Tirado, José M. García, Shilpa J Buch, Anil Kumar

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

Original languageEnglish (US)
Pages (from-to)373-383
Number of pages11
JournalVirology
Volume358
Issue number2
DOIs
StatePublished - Feb 20 2007

Fingerprint

Macaca
Morphine
Disease Progression
Morphine Dependence
Acquired Immunodeficiency Syndrome
Infection

Keywords

  • Envelope evolution
  • Macaque
  • Morphine
  • SHIV
  • SIV
  • Variable region

ASJC Scopus subject areas

  • Virology

Cite this

Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. / Rivera-Amill, Vanessa; Noel, Richard J.; Orsini, Suheydi; Tirado, Griselle; García, José M.; Buch, Shilpa J; Kumar, Anil.

In: Virology, Vol. 358, No. 2, 20.02.2007, p. 373-383.

Research output: Contribution to journalArticle

Rivera-Amill, Vanessa ; Noel, Richard J. ; Orsini, Suheydi ; Tirado, Griselle ; García, José M. ; Buch, Shilpa J ; Kumar, Anil. / Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV. In: Virology. 2007 ; Vol. 358, No. 2. pp. 373-383.
@article{d3c00b6664c148949667a658d82bd7f7,
title = "Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV",
abstract = "We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.",
keywords = "Envelope evolution, Macaque, Morphine, SHIV, SIV, Variable region",
author = "Vanessa Rivera-Amill and Noel, {Richard J.} and Suheydi Orsini and Griselle Tirado and Garc{\'i}a, {Jos{\'e} M.} and Buch, {Shilpa J} and Anil Kumar",
year = "2007",
month = "2",
day = "20",
doi = "10.1016/j.virol.2006.08.039",
language = "English (US)",
volume = "358",
pages = "373--383",
journal = "Virology",
issn = "0042-6822",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Variable region 4 of SIV envelope correlates with rapid disease progression in morphine-exposed macaques infected with SIV/SHIV

AU - Rivera-Amill, Vanessa

AU - Noel, Richard J.

AU - Orsini, Suheydi

AU - Tirado, Griselle

AU - García, José M.

AU - Buch, Shilpa J

AU - Kumar, Anil

PY - 2007/2/20

Y1 - 2007/2/20

N2 - We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

AB - We analyzed the association between the evolution of the V3-V5 regions of env and disease progression in our SIV/SHIV macaque model of morphine dependence and AIDS. Previous studies revealed two distinct disease patterns-fast progression and normal progression. To determine the effect of the two distinct patterns of disease in the evolution of SIV/17E-Fr envelope, we analyzed env sequences from three morphine-dependent macaques that developed accelerated AIDS and three morphine-dependent macaques that developed AIDS at a slower rate and compared them to control macaques. Morphine-dependent animals exhibited a higher percentage of diversity in both plasma and CSF compartments within V4 when compared to controls. Divergence from the inoculum was significantly greater in the morphine group as compared to controls in CSF but not in plasma. We also found a direct correlation in V4 evolution and rapid disease progression. These results indicate that morphine dependence plays a role in the pathogenesis of SIV/SHIV infection and env evolution.

KW - Envelope evolution

KW - Macaque

KW - Morphine

KW - SHIV

KW - SIV

KW - Variable region

UR - http://www.scopus.com/inward/record.url?scp=33846351180&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846351180&partnerID=8YFLogxK

U2 - 10.1016/j.virol.2006.08.039

DO - 10.1016/j.virol.2006.08.039

M3 - Article

VL - 358

SP - 373

EP - 383

JO - Virology

JF - Virology

SN - 0042-6822

IS - 2

ER -