Variable convalescence and therapy after cadaveric renal transplantation under cyclosporin A and steroids

T. E. Starzl, T. R. Hakala, J. T. Rosenthal, S. Iwatsuki, B. W. Shaw

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Abstract

The postoperative convalescence period was analyzed for 42 consecutive patients who had cadaveric renal transplantation under therapy with cyclosporin A and steroids. Twenty-two of the patients underwent transplantation for the first time, and the other 20 had retransplantation. None of the recipients has died. With follow-up period of two to eight months, the survival rate of grafts is 96 per cent after first transplantation and 85 per cent after retransplantation. Immunosuppression with a standard regimen was used for all patients at the outset. Early convalescence was highly variable, often necessitating adjustments of cyclosporin A and steroid dosage to accommodate the possibilities of rejection or cyclosporin A nephrotoxicity, or both, simultaneously. Management problems were more frequent and complex in patients undergoing retransplantation. From the results, a classification of convalescence patterns was evolved, with recommendations about how standardized initial therapy should be adjusted if the renal graft does not function promptly or deteriorates later.

Original languageEnglish (US)
Pages (from-to)819-825
Number of pages7
JournalSurgery Gynecology and Obstetrics
Volume154
Issue number6
StatePublished - Sep 20 1982

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ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology

Cite this

Starzl, T. E., Hakala, T. R., Rosenthal, J. T., Iwatsuki, S., & Shaw, B. W. (1982). Variable convalescence and therapy after cadaveric renal transplantation under cyclosporin A and steroids. Surgery Gynecology and Obstetrics, 154(6), 819-825.