Variability of patterns of fatigue and quality of life over time based on different breast cancer adjuvant chemotherapy regimens

Ann M. Berger, Kari Lockhart, Sangeeta Agrawal

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose/Objectives: To examine the relationships among fatigue and physical and mental quality of life (QOL) and different adjuvant chemotherapy regimens in patients with stage I-IIIA breast cancer prior to, during, and after treatment. Design: Longitudinal, descriptive design embedded in a randomized, clinical trial. Setting: Outpatient oncology clinics in the midwestern United States. Sample: 196 postoperative women, mean age of 52 years, receiving anthracycline-based chemotherapy regimens: dose-dense taxane, dose-standard taxane, or dose-standard without taxane. Methods: The Piper Fatigue Scale and Medical Outcomes Study SF-36® (v.2) Survey were completed 48 hours prior to treatment 1, at treatments 4 and 8, and 30 days after the final treatment. Main Research Variables: Fatigue, adjuvant chemotherapy regimen, and QOL. Findings: Fatigue and mental QOL changed significantly over time for all regimens, but the patterns of change did not differ based on regimen. Physical QOL changed significantly over time for all regimens, and the pattern of change differed based on whether taxanes were received. Higher fatigue was correlated with lower physical and mental QOL prior to and 30 days after the final treatment, regardless of regimen. Conclusions: Women who receive taxanes are at higher risk for lower physical QOL over time. Higher fatigue was associated with lower QOL regardless of the chemotherapy regimens. Implications for Nursing: Clinicians should screen patients for fatigue and assess for contributing factors at clinic visits. Methods to integrate evidence-based fatigue interventions into practice should be tested and outcomes evaluated.

Original languageEnglish (US)
Pages (from-to)563-570
Number of pages8
JournalOncology nursing forum
Volume36
Issue number5
DOIs
StatePublished - Sep 1 2009

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Adjuvant Chemotherapy
Fatigue
Quality of Life
Breast Neoplasms
Mental Fatigue
Taxoids
Midwestern United States
Piper
Therapeutics
Drug Therapy
Anthracyclines
Ambulatory Care
Ambulatory Care Facilities
Nursing
Randomized Controlled Trials
Outcome Assessment (Health Care)
Research
taxane

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

Variability of patterns of fatigue and quality of life over time based on different breast cancer adjuvant chemotherapy regimens. / Berger, Ann M.; Lockhart, Kari; Agrawal, Sangeeta.

In: Oncology nursing forum, Vol. 36, No. 5, 01.09.2009, p. 563-570.

Research output: Contribution to journalArticle

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