Variability in zidovudine serum concentrations

Courtney V. Fletcher, Henry H. Balfour

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study explored the variability of zidovudine concentrations with computer simulations anti measured concentrations. A one-compartment oral absorption model was selected to characterize zidovudine disposition. Mean (± standard deviation) values for the pharmacokinetic parameters were taken from the literature. Five different Monte Carlo simulations (50 each) were performed of zidovudine concentrations following repetitive administration of 100-mg oral doses 6 times/day in patients weighing 45-85 kg. A sixth simulation considered a weight-adjusted regimen. Predicted concentrations were compared with those measured in 30 HIV-infected persons receiving 100 mg/dose. Predicted concentrations 1 hour after 100 mg was administered fell in the range of 0.52-5.18 μM; measured values in 30 patients were 0.54-3.07 μM. This study confirms substantial variability in zidovudine serum concentrations. The simulation study of a weight-adjusted regimen suggests one possibility to reduce this variability. These observations provide a basis to explore dosing strategies that control for pharmacokinetic and perhaps pharmacodynamic sources of interpatient variability.

Original languageEnglish (US)
Pages (from-to)1154-1158
Number of pages5
JournalPharmacotherapy
Volume16
Issue number6 I
StatePublished - Nov 1 1996

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Zidovudine
Serum
Pharmacokinetics
Weights and Measures
Computer Simulation
HIV

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Fletcher, C. V., & Balfour, H. H. (1996). Variability in zidovudine serum concentrations. Pharmacotherapy, 16(6 I), 1154-1158.

Variability in zidovudine serum concentrations. / Fletcher, Courtney V.; Balfour, Henry H.

In: Pharmacotherapy, Vol. 16, No. 6 I, 01.11.1996, p. 1154-1158.

Research output: Contribution to journalArticle

Fletcher, CV & Balfour, HH 1996, 'Variability in zidovudine serum concentrations', Pharmacotherapy, vol. 16, no. 6 I, pp. 1154-1158.
Fletcher, Courtney V. ; Balfour, Henry H. / Variability in zidovudine serum concentrations. In: Pharmacotherapy. 1996 ; Vol. 16, No. 6 I. pp. 1154-1158.
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