Validation of a combined comorbidity index

Mary Charlson, Ted P. Szatrowski, Janey Peterson, Jeffrey P Gold

Research output: Contribution to journalArticle

2734 Citations (Scopus)

Abstract

The basic objective of this paper is to evaluate an age-comorbidity index in a cohort of patients who were originally enrolled in a prospective study to identify risk factors for peri-operative complications. Two-hundred and twenty-six patients were enrolled in the study. The participants were patients with hypertension or diabetes who underwent elective surgery between 1982 and 1985 and who survived to discharge. Two-hundred and eighteen patients survived until discharge. These patients were followed for at least five years post-operatively. The estimated relative risk of death for each comorbidity rank was 1.4 and for each decade of age was 1.4. When age and comorbidity were modelled as a combined age-comorbidity score, the estimated relative risk for each combined age-comorbidity unit was 1.45. Thus, the estimated relative risk of death from an increase of one in the comorbidity score proved approximately equal to that from an additional decade of age. The combined age-comorbidity score may be useful in some longitudinal studies to estimate relative risk of death from prognostic clinical covariates.

Original languageEnglish (US)
Pages (from-to)1245-1251
Number of pages7
JournalJournal of Clinical Epidemiology
Volume47
Issue number11
DOIs
StatePublished - Jan 1 1994

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Comorbidity
Longitudinal Studies
Prospective Studies
Hypertension

Keywords

  • Comorbidity
  • Prognosis

ASJC Scopus subject areas

  • Epidemiology

Cite this

Validation of a combined comorbidity index. / Charlson, Mary; Szatrowski, Ted P.; Peterson, Janey; Gold, Jeffrey P.

In: Journal of Clinical Epidemiology, Vol. 47, No. 11, 01.01.1994, p. 1245-1251.

Research output: Contribution to journalArticle

Charlson, Mary ; Szatrowski, Ted P. ; Peterson, Janey ; Gold, Jeffrey P. / Validation of a combined comorbidity index. In: Journal of Clinical Epidemiology. 1994 ; Vol. 47, No. 11. pp. 1245-1251.
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