Vagal C-fiber blockade abolishes sympathetic inhibition by atrial natriuretic factor

Harold D Schultz, D. G. Gardner, C. F. Deschepper, H. M. Coleridge, J. C.G. Coleridge

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine. We sought to determine whether afferent vagal C-fibers mediate the inhibition of sympathetic outflow. ANF (2.5 μg/kg iv) decreased mean arterial pressure (MAP) by 25 ± 2 mmHg, RNA by 11 ± 5%, and least splanchnic nerve activity (LSNA) by 10 ± 4% in anesthetized rats with arterial baroreceptors intact, and by 40 ± 3 mmHg, 28 ± 7%, and 23 ± 4%, respectively, in sinoaortic-denervated rats. Inhibition of RNA and LSNA by ANF was reduced slightly by cooling the vagi to 6 or 7°C, a temperature at which conduction in A-fibers was blocked and that in C-fibers attenuated; inhibition was abolished when C-fibers were blocked by cooling to 0°C. We conclude that the inhibition of RNA and LSNA by ANF was mediated by afferent vagal C-fibers. We also obtained evidence that the aortic nerves contribute to ANF-induced inhibition of RNA. Our results support the notion that ANF evokes a generalized decrease in sympathetic tone that contributes to the hypotension, cardiac inhibition, and natriuresis accompanying systemic administration of the peptide.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume255
Issue number1
StatePublished - Jan 1 1988
Externally publishedYes

Fingerprint

Unmyelinated Nerve Fibers
Atrial Natriuretic Factor
Splanchnic Nerves
Kidney
Myelinated Nerve Fibers
Natriuresis
Pressoreceptors
Vagotomy
Atropine
Hypotension
Arterial Pressure
Peptides
Temperature

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Vagal C-fiber blockade abolishes sympathetic inhibition by atrial natriuretic factor. / Schultz, Harold D; Gardner, D. G.; Deschepper, C. F.; Coleridge, H. M.; Coleridge, J. C.G.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 255, No. 1, 01.01.1988.

Research output: Contribution to journalArticle

@article{ce01c2a1468f49eaa43742cb22a45401,
title = "Vagal C-fiber blockade abolishes sympathetic inhibition by atrial natriuretic factor",
abstract = "Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine. We sought to determine whether afferent vagal C-fibers mediate the inhibition of sympathetic outflow. ANF (2.5 μg/kg iv) decreased mean arterial pressure (MAP) by 25 ± 2 mmHg, RNA by 11 ± 5{\%}, and least splanchnic nerve activity (LSNA) by 10 ± 4{\%} in anesthetized rats with arterial baroreceptors intact, and by 40 ± 3 mmHg, 28 ± 7{\%}, and 23 ± 4{\%}, respectively, in sinoaortic-denervated rats. Inhibition of RNA and LSNA by ANF was reduced slightly by cooling the vagi to 6 or 7°C, a temperature at which conduction in A-fibers was blocked and that in C-fibers attenuated; inhibition was abolished when C-fibers were blocked by cooling to 0°C. We conclude that the inhibition of RNA and LSNA by ANF was mediated by afferent vagal C-fibers. We also obtained evidence that the aortic nerves contribute to ANF-induced inhibition of RNA. Our results support the notion that ANF evokes a generalized decrease in sympathetic tone that contributes to the hypotension, cardiac inhibition, and natriuresis accompanying systemic administration of the peptide.",
author = "Schultz, {Harold D} and Gardner, {D. G.} and Deschepper, {C. F.} and Coleridge, {H. M.} and Coleridge, {J. C.G.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "255",
journal = "American Journal of Physiology - Renal Physiology",
issn = "0363-6127",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Vagal C-fiber blockade abolishes sympathetic inhibition by atrial natriuretic factor

AU - Schultz, Harold D

AU - Gardner, D. G.

AU - Deschepper, C. F.

AU - Coleridge, H. M.

AU - Coleridge, J. C.G.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine. We sought to determine whether afferent vagal C-fibers mediate the inhibition of sympathetic outflow. ANF (2.5 μg/kg iv) decreased mean arterial pressure (MAP) by 25 ± 2 mmHg, RNA by 11 ± 5%, and least splanchnic nerve activity (LSNA) by 10 ± 4% in anesthetized rats with arterial baroreceptors intact, and by 40 ± 3 mmHg, 28 ± 7%, and 23 ± 4%, respectively, in sinoaortic-denervated rats. Inhibition of RNA and LSNA by ANF was reduced slightly by cooling the vagi to 6 or 7°C, a temperature at which conduction in A-fibers was blocked and that in C-fibers attenuated; inhibition was abolished when C-fibers were blocked by cooling to 0°C. We conclude that the inhibition of RNA and LSNA by ANF was mediated by afferent vagal C-fibers. We also obtained evidence that the aortic nerves contribute to ANF-induced inhibition of RNA. Our results support the notion that ANF evokes a generalized decrease in sympathetic tone that contributes to the hypotension, cardiac inhibition, and natriuresis accompanying systemic administration of the peptide.

AB - Administration of atrial natriuretic factor (ANF) to anesthetized rats decreases renal nerve activity (RNA), an effect prevented by vagotomy but not by atropine. We sought to determine whether afferent vagal C-fibers mediate the inhibition of sympathetic outflow. ANF (2.5 μg/kg iv) decreased mean arterial pressure (MAP) by 25 ± 2 mmHg, RNA by 11 ± 5%, and least splanchnic nerve activity (LSNA) by 10 ± 4% in anesthetized rats with arterial baroreceptors intact, and by 40 ± 3 mmHg, 28 ± 7%, and 23 ± 4%, respectively, in sinoaortic-denervated rats. Inhibition of RNA and LSNA by ANF was reduced slightly by cooling the vagi to 6 or 7°C, a temperature at which conduction in A-fibers was blocked and that in C-fibers attenuated; inhibition was abolished when C-fibers were blocked by cooling to 0°C. We conclude that the inhibition of RNA and LSNA by ANF was mediated by afferent vagal C-fibers. We also obtained evidence that the aortic nerves contribute to ANF-induced inhibition of RNA. Our results support the notion that ANF evokes a generalized decrease in sympathetic tone that contributes to the hypotension, cardiac inhibition, and natriuresis accompanying systemic administration of the peptide.

UR - http://www.scopus.com/inward/record.url?scp=0023733999&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023733999&partnerID=8YFLogxK

M3 - Article

VL - 255

JO - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

SN - 0363-6127

IS - 1

ER -