In the yeast Saccharomyces cerevisiae the PEP4 gene product, protease A, is responsible for activating all soluble vacuolar (lysosomal) enzymes. These vacuolar enzymes remain inactive in pep4 mutants. Vacuolar trehalase activity was diminished in such mutants as well. This suggests that the vacuolar (lysosomal) trehalase is processed in a manner similar to other vacuolar enzymes in S. cerevisiae.
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology