Vaccine technologies against avian influenza: Current approaches and new directions

Kathleen A. Ross, Lucas M. Huntimer, Julia E. Vela Ramirez, Justin R. Adams, Susan L. Carpenter, Marian L. Kohut, Tatiana Bronich, Richard Webby, Kevin L. Legge, Surya K. Mallapragada, Michael J. Wannemuehler, Balaji Narasimhan

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

The potential epidemiological human pandemic resulting from highly pathogenic avian influenza (HPAI) H5N1 has been studied extensively since the identification of the virus in the Guangdong province of China. The majority of research has focused on the unique and severe histopathological lesions induced by the virus. The severe pathological presentation of these infections has also prompted interest in identifying preventive and therapeutic approaches against HPAI. The potential severity of a HPAI pandemic and the efforts to identify effective intervention strategies have led to many novel discoveries in vaccine and antiviral development that are critically examined in this review.

Original languageEnglish (US)
Pages (from-to)2261-2294
Number of pages34
JournalJournal of Biomedical Nanotechnology
Volume10
Issue number9
DOIs
StatePublished - Sep 2014

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Keywords

  • Antiviral
  • H5N1
  • Highly pathogenic avian influenza
  • Pandemic
  • Vaccine

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Ross, K. A., Huntimer, L. M., Vela Ramirez, J. E., Adams, J. R., Carpenter, S. L., Kohut, M. L., Bronich, T., Webby, R., Legge, K. L., Mallapragada, S. K., Wannemuehler, M. J., & Narasimhan, B. (2014). Vaccine technologies against avian influenza: Current approaches and new directions. Journal of Biomedical Nanotechnology, 10(9), 2261-2294. https://doi.org/10.1166/jbn.2014.1983