Vaccination of swine with an inactivated porcine parvovirus vaccine in the presence of passive immunity.

P. S. Paul, W. L. Mengeling

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A study was conducted to determine whether low hemagglutination inhibiting (HI) titers (1:5) for porcine parvovirus (PPV) block the development of immune response to a PPV vaccine. Pigs with low (1:5), medium (1:10 or 1:20), or high (1:40 or 1:80) titers were obtained by IV injections with various amounts of PPV immune serum. Pigs were inoculated with 1 or 2 doses of vaccine and were monitored for serum HI antibodies to PPV. Pigs with low titers responded to vaccine just as well as did the seronegative pigs. The HI titers of pigs with medium titers did not increase after first vaccination. After the second vaccination, however, their titers increased and were similar to those of pigs with low titers. High titers blocked the response to vaccination. The pigs that received 2 doses of vaccine had higher titers than did those of pigs that received 1 dose of vaccine. The results indicated that low titers, which would be expected in gilts at the time of vaccination, do not interfere with immunization by the inactivated PPV vaccine, and that 2 doses of vaccine may provide better and longer lasting immune response to inactivated PPV vaccine and probably longer lasting immunity against PPV-induced reproductive failure.

Original languageEnglish (US)
Pages (from-to)410-413
Number of pages4
JournalJournal of the American Veterinary Medical Association
Volume188
Issue number4
StatePublished - Feb 15 1986

Fingerprint

Porcine Parvovirus
Ungulate protoparvovirus 1
passive immunity
Immunity
Vaccination
Swine
Vaccines
vaccination
vaccines
swine
Hemagglutination
hemagglutination
dosage
immune response
blood serum
gilts
intravenous injection
antiserum
Immune Sera
Immunization

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Vaccination of swine with an inactivated porcine parvovirus vaccine in the presence of passive immunity. / Paul, P. S.; Mengeling, W. L.

In: Journal of the American Veterinary Medical Association, Vol. 188, No. 4, 15.02.1986, p. 410-413.

Research output: Contribution to journalArticle

@article{5a9861173af3472c940ba2b65c6f9a30,
title = "Vaccination of swine with an inactivated porcine parvovirus vaccine in the presence of passive immunity.",
abstract = "A study was conducted to determine whether low hemagglutination inhibiting (HI) titers (1:5) for porcine parvovirus (PPV) block the development of immune response to a PPV vaccine. Pigs with low (1:5), medium (1:10 or 1:20), or high (1:40 or 1:80) titers were obtained by IV injections with various amounts of PPV immune serum. Pigs were inoculated with 1 or 2 doses of vaccine and were monitored for serum HI antibodies to PPV. Pigs with low titers responded to vaccine just as well as did the seronegative pigs. The HI titers of pigs with medium titers did not increase after first vaccination. After the second vaccination, however, their titers increased and were similar to those of pigs with low titers. High titers blocked the response to vaccination. The pigs that received 2 doses of vaccine had higher titers than did those of pigs that received 1 dose of vaccine. The results indicated that low titers, which would be expected in gilts at the time of vaccination, do not interfere with immunization by the inactivated PPV vaccine, and that 2 doses of vaccine may provide better and longer lasting immune response to inactivated PPV vaccine and probably longer lasting immunity against PPV-induced reproductive failure.",
author = "Paul, {P. S.} and Mengeling, {W. L.}",
year = "1986",
month = "2",
day = "15",
language = "English (US)",
volume = "188",
pages = "410--413",
journal = "Journal of the American Veterinary Medical Association",
issn = "0003-1488",
publisher = "American Veterinary Medical Association",
number = "4",

}

TY - JOUR

T1 - Vaccination of swine with an inactivated porcine parvovirus vaccine in the presence of passive immunity.

AU - Paul, P. S.

AU - Mengeling, W. L.

PY - 1986/2/15

Y1 - 1986/2/15

N2 - A study was conducted to determine whether low hemagglutination inhibiting (HI) titers (1:5) for porcine parvovirus (PPV) block the development of immune response to a PPV vaccine. Pigs with low (1:5), medium (1:10 or 1:20), or high (1:40 or 1:80) titers were obtained by IV injections with various amounts of PPV immune serum. Pigs were inoculated with 1 or 2 doses of vaccine and were monitored for serum HI antibodies to PPV. Pigs with low titers responded to vaccine just as well as did the seronegative pigs. The HI titers of pigs with medium titers did not increase after first vaccination. After the second vaccination, however, their titers increased and were similar to those of pigs with low titers. High titers blocked the response to vaccination. The pigs that received 2 doses of vaccine had higher titers than did those of pigs that received 1 dose of vaccine. The results indicated that low titers, which would be expected in gilts at the time of vaccination, do not interfere with immunization by the inactivated PPV vaccine, and that 2 doses of vaccine may provide better and longer lasting immune response to inactivated PPV vaccine and probably longer lasting immunity against PPV-induced reproductive failure.

AB - A study was conducted to determine whether low hemagglutination inhibiting (HI) titers (1:5) for porcine parvovirus (PPV) block the development of immune response to a PPV vaccine. Pigs with low (1:5), medium (1:10 or 1:20), or high (1:40 or 1:80) titers were obtained by IV injections with various amounts of PPV immune serum. Pigs were inoculated with 1 or 2 doses of vaccine and were monitored for serum HI antibodies to PPV. Pigs with low titers responded to vaccine just as well as did the seronegative pigs. The HI titers of pigs with medium titers did not increase after first vaccination. After the second vaccination, however, their titers increased and were similar to those of pigs with low titers. High titers blocked the response to vaccination. The pigs that received 2 doses of vaccine had higher titers than did those of pigs that received 1 dose of vaccine. The results indicated that low titers, which would be expected in gilts at the time of vaccination, do not interfere with immunization by the inactivated PPV vaccine, and that 2 doses of vaccine may provide better and longer lasting immune response to inactivated PPV vaccine and probably longer lasting immunity against PPV-induced reproductive failure.

UR - http://www.scopus.com/inward/record.url?scp=0023049111&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023049111&partnerID=8YFLogxK

M3 - Article

C2 - 3949618

AN - SCOPUS:0023049111

VL - 188

SP - 410

EP - 413

JO - Journal of the American Veterinary Medical Association

JF - Journal of the American Veterinary Medical Association

SN - 0003-1488

IS - 4

ER -