Uveitis in Patients with Autoimmune Hepatitis

Lyndell L. Lim, John D. Scarborough, Jennifer E. Thorne, Elizabeth Graham, John H. Kempen, Friederike Mackensen, Quan Dong Nguyen, Tisha Prabriputaloong, Russell W. Read, Eric B. Suhler, Jonathan M. Schwartz, Justine R. Smith

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose: To report seven cases of uveitis occurring in patients with autoimmune hepatitis (AIH), raising the possibility that uveitis may be an extrahepatic feature of AIH. Design: Multicenter, retrospective, observational case series of patients with AIH and uveitis. Methods: One index case was identified at Oregon Health & Science University. Further cases were identified by a web-based survey of members of the American Uveitis Society, the International Uveitis Study Group, the Proctor Foundation mailing list server, and the First SUN International Workshop. Respondents were asked to provide clinical information about uveitis phenotype, AIH features, and treatment. Results: Clinical information was obtained for seven individuals (four females and three males; age range, seven to 67 years) who suffered from AIH and uveitis. Average duration of follow-up was 5.5 years. All patients had chronic, persistent bilateral uveitis that was anterior (n = 3), intermediate (n = 1), or pan (n = 3) in location. Every patient had complications arising from his or her uveitis, including cataract (n = 5), glaucoma (n = 3), cystoid macular edema (n = 3), and posterior synechiae (n = 3). Final visual acuities ranged from 20/16 to hand movements. To treat the uveitis and/or AIH, the majority of patients required oral prednisone and all seven patients were treated with systemic immunosuppression. Conclusion: Despite the small size of this study, our findings suggest an association between AIH and uveitis. The uveitis is chronic, bilateral, and associated with sight-threatening complications, necessitating systemic immunosuppression in some individuals.

Original languageEnglish (US)
JournalAmerican journal of ophthalmology
Volume147
Issue number2
DOIs
StatePublished - Jan 1 2009

Fingerprint

Autoimmune Hepatitis
Uveitis
Immunosuppression
Anterior Uveitis
Macular Edema
Prednisone
Glaucoma
Cataract
Visual Acuity
Hand
Phenotype
Education

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lim, L. L., Scarborough, J. D., Thorne, J. E., Graham, E., Kempen, J. H., Mackensen, F., ... Smith, J. R. (2009). Uveitis in Patients with Autoimmune Hepatitis. American journal of ophthalmology, 147(2). https://doi.org/10.1016/j.ajo.2008.08.019

Uveitis in Patients with Autoimmune Hepatitis. / Lim, Lyndell L.; Scarborough, John D.; Thorne, Jennifer E.; Graham, Elizabeth; Kempen, John H.; Mackensen, Friederike; Nguyen, Quan Dong; Prabriputaloong, Tisha; Read, Russell W.; Suhler, Eric B.; Schwartz, Jonathan M.; Smith, Justine R.

In: American journal of ophthalmology, Vol. 147, No. 2, 01.01.2009.

Research output: Contribution to journalArticle

Lim, LL, Scarborough, JD, Thorne, JE, Graham, E, Kempen, JH, Mackensen, F, Nguyen, QD, Prabriputaloong, T, Read, RW, Suhler, EB, Schwartz, JM & Smith, JR 2009, 'Uveitis in Patients with Autoimmune Hepatitis', American journal of ophthalmology, vol. 147, no. 2. https://doi.org/10.1016/j.ajo.2008.08.019
Lim LL, Scarborough JD, Thorne JE, Graham E, Kempen JH, Mackensen F et al. Uveitis in Patients with Autoimmune Hepatitis. American journal of ophthalmology. 2009 Jan 1;147(2). https://doi.org/10.1016/j.ajo.2008.08.019
Lim, Lyndell L. ; Scarborough, John D. ; Thorne, Jennifer E. ; Graham, Elizabeth ; Kempen, John H. ; Mackensen, Friederike ; Nguyen, Quan Dong ; Prabriputaloong, Tisha ; Read, Russell W. ; Suhler, Eric B. ; Schwartz, Jonathan M. ; Smith, Justine R. / Uveitis in Patients with Autoimmune Hepatitis. In: American journal of ophthalmology. 2009 ; Vol. 147, No. 2.
@article{74adf071659c4db08603a7cef1b36b06,
title = "Uveitis in Patients with Autoimmune Hepatitis",
abstract = "Purpose: To report seven cases of uveitis occurring in patients with autoimmune hepatitis (AIH), raising the possibility that uveitis may be an extrahepatic feature of AIH. Design: Multicenter, retrospective, observational case series of patients with AIH and uveitis. Methods: One index case was identified at Oregon Health & Science University. Further cases were identified by a web-based survey of members of the American Uveitis Society, the International Uveitis Study Group, the Proctor Foundation mailing list server, and the First SUN International Workshop. Respondents were asked to provide clinical information about uveitis phenotype, AIH features, and treatment. Results: Clinical information was obtained for seven individuals (four females and three males; age range, seven to 67 years) who suffered from AIH and uveitis. Average duration of follow-up was 5.5 years. All patients had chronic, persistent bilateral uveitis that was anterior (n = 3), intermediate (n = 1), or pan (n = 3) in location. Every patient had complications arising from his or her uveitis, including cataract (n = 5), glaucoma (n = 3), cystoid macular edema (n = 3), and posterior synechiae (n = 3). Final visual acuities ranged from 20/16 to hand movements. To treat the uveitis and/or AIH, the majority of patients required oral prednisone and all seven patients were treated with systemic immunosuppression. Conclusion: Despite the small size of this study, our findings suggest an association between AIH and uveitis. The uveitis is chronic, bilateral, and associated with sight-threatening complications, necessitating systemic immunosuppression in some individuals.",
author = "Lim, {Lyndell L.} and Scarborough, {John D.} and Thorne, {Jennifer E.} and Elizabeth Graham and Kempen, {John H.} and Friederike Mackensen and Nguyen, {Quan Dong} and Tisha Prabriputaloong and Read, {Russell W.} and Suhler, {Eric B.} and Schwartz, {Jonathan M.} and Smith, {Justine R.}",
year = "2009",
month = "1",
day = "1",
doi = "10.1016/j.ajo.2008.08.019",
language = "English (US)",
volume = "147",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "2",

}

TY - JOUR

T1 - Uveitis in Patients with Autoimmune Hepatitis

AU - Lim, Lyndell L.

AU - Scarborough, John D.

AU - Thorne, Jennifer E.

AU - Graham, Elizabeth

AU - Kempen, John H.

AU - Mackensen, Friederike

AU - Nguyen, Quan Dong

AU - Prabriputaloong, Tisha

AU - Read, Russell W.

AU - Suhler, Eric B.

AU - Schwartz, Jonathan M.

AU - Smith, Justine R.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Purpose: To report seven cases of uveitis occurring in patients with autoimmune hepatitis (AIH), raising the possibility that uveitis may be an extrahepatic feature of AIH. Design: Multicenter, retrospective, observational case series of patients with AIH and uveitis. Methods: One index case was identified at Oregon Health & Science University. Further cases were identified by a web-based survey of members of the American Uveitis Society, the International Uveitis Study Group, the Proctor Foundation mailing list server, and the First SUN International Workshop. Respondents were asked to provide clinical information about uveitis phenotype, AIH features, and treatment. Results: Clinical information was obtained for seven individuals (four females and three males; age range, seven to 67 years) who suffered from AIH and uveitis. Average duration of follow-up was 5.5 years. All patients had chronic, persistent bilateral uveitis that was anterior (n = 3), intermediate (n = 1), or pan (n = 3) in location. Every patient had complications arising from his or her uveitis, including cataract (n = 5), glaucoma (n = 3), cystoid macular edema (n = 3), and posterior synechiae (n = 3). Final visual acuities ranged from 20/16 to hand movements. To treat the uveitis and/or AIH, the majority of patients required oral prednisone and all seven patients were treated with systemic immunosuppression. Conclusion: Despite the small size of this study, our findings suggest an association between AIH and uveitis. The uveitis is chronic, bilateral, and associated with sight-threatening complications, necessitating systemic immunosuppression in some individuals.

AB - Purpose: To report seven cases of uveitis occurring in patients with autoimmune hepatitis (AIH), raising the possibility that uveitis may be an extrahepatic feature of AIH. Design: Multicenter, retrospective, observational case series of patients with AIH and uveitis. Methods: One index case was identified at Oregon Health & Science University. Further cases were identified by a web-based survey of members of the American Uveitis Society, the International Uveitis Study Group, the Proctor Foundation mailing list server, and the First SUN International Workshop. Respondents were asked to provide clinical information about uveitis phenotype, AIH features, and treatment. Results: Clinical information was obtained for seven individuals (four females and three males; age range, seven to 67 years) who suffered from AIH and uveitis. Average duration of follow-up was 5.5 years. All patients had chronic, persistent bilateral uveitis that was anterior (n = 3), intermediate (n = 1), or pan (n = 3) in location. Every patient had complications arising from his or her uveitis, including cataract (n = 5), glaucoma (n = 3), cystoid macular edema (n = 3), and posterior synechiae (n = 3). Final visual acuities ranged from 20/16 to hand movements. To treat the uveitis and/or AIH, the majority of patients required oral prednisone and all seven patients were treated with systemic immunosuppression. Conclusion: Despite the small size of this study, our findings suggest an association between AIH and uveitis. The uveitis is chronic, bilateral, and associated with sight-threatening complications, necessitating systemic immunosuppression in some individuals.

UR - http://www.scopus.com/inward/record.url?scp=58249098858&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58249098858&partnerID=8YFLogxK

U2 - 10.1016/j.ajo.2008.08.019

DO - 10.1016/j.ajo.2008.08.019

M3 - Article

VL - 147

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 2

ER -