### Abstract

A method for the estimation of genetic correlations based upon analysis of genetic marker phenotypes is presented. At given marker locus, the probability of observing a pair of individuals with a specific combination of phenotypes can be expressed as a function of the gene frequencies at that locus and the genetic correlation (R) between that pair. The likelihood of obtaining a smaple of n such pairs with their phenotypes at m marker loci can be expressed as a product of nm such functions. From the likelihood function, maximum estimates of R can be obtained, and hypotheses about R may be tested. A sample of Swedish twin families (61 dizygotic twin pairs, 268 husband-wife pairs, and 164 sib pairs) were analyzed by this method using information from 21 markers. It was found that for the twin pairs, R=0.458, which was significantly different from the R calculated for sib pairs (R=0.558) but not significantly different from the expected 0.5. For the husband-wife pairs, it was found that R=0.086, which did differ significantly from the expected value of 0, indicating the presence of nonrandom mating in this population.

Original language | English (US) |
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Pages (from-to) | 255-262 |

Number of pages | 8 |

Journal | Acta Geneticae Medicae et Gemellologiae |

Volume | 29 |

Issue number | 4 |

DOIs | |

State | Published - Jan 1 1980 |

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### ASJC Scopus subject areas

- Genetics(clinical)

### Cite this

*Acta Geneticae Medicae et Gemellologiae*,

*29*(4), 255-262. https://doi.org/10.1017/S0001566000007765