USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst

Andre M. Oliveira, Bae Li Hsi, Stanislawa Weremowicz, Andrew E. Rosenberg, Paola Dal Cin, Nora Joseph, Julia A. Bridge, Antonio R. Perez-Atayde, Jonathan A. Fletcher

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Aneurysmal bone cyst (ABC) is a locally aggressive osseous lesion that typically occurs during the first two decades of life. ABC was regarded historically as a nonneoplastic process, but recent cytogenetic data have shown clonal rearrangements of chromosomal bands 16q22 and 17p13, indicating a neoplastic basis in at least some ABCs. Herein we show that a recurring ABC chromosomal translocation t(16;17)(q22;p13) creates a fusion gene in which the osteoblast cadherin 11 gene (CDH11) promoter region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence on 17p13. CDH11-USP6 fusion transcripts were demonstrated only in ABC with t(16;17) but other ABCs had CDH11 or USP6 rearrangements resulting from alternate cytogenetic mechanisms. CDH11 is expressed strongly in bone, and our findings implicate a novel oncogenic mechanism in which deregulated USP6 transcription results from juxtaposition to the highly active CDH11 promoter.

Original languageEnglish (US)
Pages (from-to)1920-1923
Number of pages4
JournalCancer Research
Volume64
Issue number6
DOIs
StatePublished - Mar 15 2004

Fingerprint

Oncogene Fusion
Aneurysmal Bone Cysts
Gene Fusion
Cytogenetics
Genes
Ubiquitin-Specific Proteases
Genetic Translocation
Genetic Promoter Regions
osteoblast cadherin
Bone and Bones

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Oliveira, A. M., Hsi, B. L., Weremowicz, S., Rosenberg, A. E., Dal Cin, P., Joseph, N., ... Fletcher, J. A. (2004). USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst. Cancer Research, 64(6), 1920-1923. https://doi.org/10.1158/0008-5472.CAN-03-2827

USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst. / Oliveira, Andre M.; Hsi, Bae Li; Weremowicz, Stanislawa; Rosenberg, Andrew E.; Dal Cin, Paola; Joseph, Nora; Bridge, Julia A.; Perez-Atayde, Antonio R.; Fletcher, Jonathan A.

In: Cancer Research, Vol. 64, No. 6, 15.03.2004, p. 1920-1923.

Research output: Contribution to journalArticle

Oliveira, AM, Hsi, BL, Weremowicz, S, Rosenberg, AE, Dal Cin, P, Joseph, N, Bridge, JA, Perez-Atayde, AR & Fletcher, JA 2004, 'USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst', Cancer Research, vol. 64, no. 6, pp. 1920-1923. https://doi.org/10.1158/0008-5472.CAN-03-2827
Oliveira AM, Hsi BL, Weremowicz S, Rosenberg AE, Dal Cin P, Joseph N et al. USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst. Cancer Research. 2004 Mar 15;64(6):1920-1923. https://doi.org/10.1158/0008-5472.CAN-03-2827
Oliveira, Andre M. ; Hsi, Bae Li ; Weremowicz, Stanislawa ; Rosenberg, Andrew E. ; Dal Cin, Paola ; Joseph, Nora ; Bridge, Julia A. ; Perez-Atayde, Antonio R. ; Fletcher, Jonathan A. / USP6 (Tre2) Fusion Oncogenes in Aneurysmal Bone Cyst. In: Cancer Research. 2004 ; Vol. 64, No. 6. pp. 1920-1923.
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