Using murine models to investigate tumor-lymphoid interactions: Spotlight on chronic lymphocytic leukemia and angioimmunoblastic T-Cell lymphoma

Tyler A. Herek, Christine E. Cutucache

Research output: Contribution to journalReview article

1 Scopus citations


The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.

Original languageEnglish (US)
Article number86
JournalFrontiers in Oncology
Issue numberMAY
Publication statusPublished - May 2 2017



  • Angioimmunoblastic T-cell lymphoma
  • Chronic lymphocytic leukemia
  • Immune surveillance
  • Lymphoma
  • Tumor-induced immunosuppression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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