Using murine models to investigate tumor-lymphoid interactions

Spotlight on chronic lymphocytic leukemia and angioimmunoblastic T-Cell lymphoma

Tyler A. Herek, Christine E Cutucache

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.

Original languageEnglish (US)
Article number86
JournalFrontiers in Oncology
Volume7
Issue numberMAY
DOIs
StatePublished - May 2 2017

Fingerprint

T-Cell Lymphoma
B-Cell Chronic Lymphocytic Leukemia
Tumor Microenvironment
Non-Hodgkin's Lymphoma
Lymphoma
Neoplasms
Leukemia
B-Lymphocytes
Lymphocytes
T-Lymphocytes

Keywords

  • Angioimmunoblastic T-cell lymphoma
  • Chronic lymphocytic leukemia
  • Immune surveillance
  • Lymphoma
  • Tumor-induced immunosuppression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

@article{e0480ce91af44f4392b877b1e39b2878,
title = "Using murine models to investigate tumor-lymphoid interactions: Spotlight on chronic lymphocytic leukemia and angioimmunoblastic T-Cell lymphoma",
abstract = "The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.",
keywords = "Angioimmunoblastic T-cell lymphoma, Chronic lymphocytic leukemia, Immune surveillance, Lymphoma, Tumor-induced immunosuppression",
author = "Herek, {Tyler A.} and Cutucache, {Christine E}",
year = "2017",
month = "5",
day = "2",
doi = "10.3389/fonc.2017.00086",
language = "English (US)",
volume = "7",
journal = "Frontiers in Oncology",
issn = "2234-943X",
publisher = "Frontiers Media S. A.",
number = "MAY",

}

TY - JOUR

T1 - Using murine models to investigate tumor-lymphoid interactions

T2 - Spotlight on chronic lymphocytic leukemia and angioimmunoblastic T-Cell lymphoma

AU - Herek, Tyler A.

AU - Cutucache, Christine E

PY - 2017/5/2

Y1 - 2017/5/2

N2 - The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.

AB - The role of the tumor microenvironment in leukemias and lymphomas is well established, yet the intricacies of how the malignant cells regulate and influence their non-malignant counterparts remain elusive. For example, chronic lymphocytic leukemia (CLL) is an expansion of malignant CD5+CD19+ B cells, yet the non-malignant T cells play just as large of a role in disease presentation and etiology. Herein, we review the dynamic tumor cell to lymphoid repertoire interactions found in two non-Hodgkin's lymphoma subtypes: CLL and angioimmunoblastic T-cell lymphoma. We aim to highlight the pivot work done in the murine models which recapitulate these diseases and explore the insights that can be gained from studying the immuno-oncological regulation of non-malignant lymphoid counterparts.

KW - Angioimmunoblastic T-cell lymphoma

KW - Chronic lymphocytic leukemia

KW - Immune surveillance

KW - Lymphoma

KW - Tumor-induced immunosuppression

UR - http://www.scopus.com/inward/record.url?scp=85020102215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85020102215&partnerID=8YFLogxK

U2 - 10.3389/fonc.2017.00086

DO - 10.3389/fonc.2017.00086

M3 - Review article

VL - 7

JO - Frontiers in Oncology

JF - Frontiers in Oncology

SN - 2234-943X

IS - MAY

M1 - 86

ER -