Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview

Neil Carmichael, Melanie Bausen, Alan R. Boobis, Samuel Monroe Cohen, Michelle Embry, Claudia Fruijtier-Pölloth, Helmut Greim, Richard Lewis, M. E. Meek, Howard Mellor, Carolyn Vickers, John Doe

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), the International Life Sciences Institute (ILSI) Research Foundation (RF), and the ILSI Health and Environmental Sciences Institute (HESI) hosted a workshop in November 2009 to review current practice in the application of mode of action (MOA) considerations in chemical risk assessment. The aim was to provide a rationale for a more general, but flexible approach and to propose steps to facilitate broader uptake and use of the MOA concept. There was consensus amongst the workshop participants that it will require substantial effort and cooperation from the multiple disciplines involved to embrace a common, consistent, and transparent approach. Setting up a repository of accepted MOAs and associated guidance concerning appropriate data to support specific MOAs for critical effects would facilitate categorization of chemicals and allow predictions of toxicity outcomes by read-across. This should in future contribute to the reduction of toxicity testing in animals. The workshop participants also acknowledged the value and importance of human data and the importance of integrating information from biological pathway analyses into current MOA/human relevance frameworks.

Original languageEnglish (US)
Pages (from-to)175-186
Number of pages12
JournalCritical reviews in toxicology
Volume41
Issue number3
DOIs
StatePublished - Mar 1 2011

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Keywords

  • Biological pathways
  • chemical categories
  • chemical risk assessment
  • human relevance
  • key events
  • mode/modes of action (MOA/MOAs)
  • read-across

ASJC Scopus subject areas

  • Toxicology

Cite this

Carmichael, N., Bausen, M., Boobis, A. R., Cohen, S. M., Embry, M., Fruijtier-Pölloth, C., Greim, H., Lewis, R., Meek, M. E., Mellor, H., Vickers, C., & Doe, J. (2011). Using mode of action information to improve regulatory decision-making: An ECETOC/ILSI RF/HESI workshop overview. Critical reviews in toxicology, 41(3), 175-186. https://doi.org/10.3109/10408444.2010.541225