El uso de altas dosis para compensar residuos en la sonda de infusiones continuas de piperacilina-tazobactam

Translated title of the contribution: Using higher doses to compensate for tubing residuals in extended-infusion piperacillin-tazobactam

Wendy J. Lam, Tanaya Bhowmick, Alan Gross, Trevor C VanSchooneveld, Melvin P. Weinstein

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVE: To mathematically assess drug losses due to infusion line residuals and evaluate methods to compensate for drug loss due to residual volumes in intravenous pump tubing. DATA SOURCES: Literature was accessed through Ovid MEDLINE (1996-February 2013), using combinations of the search terms tubing residuals, residual volume, residual medication, intravenous infusions, intravenous injections, piperacillin, piperacillin-tazobactam, β-lactams, equipment design, infusion pumps, extended infusion, extended administration, and prolonged infusion. In addition, select reference citations from publications identified were reviewed. STUDY SELECTION AND DATA EXTRACTION: All articles that involved extended-infusion piperacillin-tazobactam implementation strategies were included in the review. DATA SYNTHESIS: Infusion pump characteristics and tubing residuals can affect extended-infusion piperacillin-tazobactam dosing strategies. Two studies addressing tubing residuals were identified. Both studies recommended increasing infusion volumes to compensate for tubing residuals. One study also recommended decreasing infusion-line dead space by using alternative infusion pump systems. Study calculations suggest that higher doses of piperacillin-tazobactam may be used to account for medication left in tubing residuals if alternative infusion pump systems cannot be obtained, and increased infusion volumes are not an option. CONCLUSIONS: Extended-infusion piperacillin-tazobactam has been used as a method of maximizing pharmacodynamic target attainment. Use of higher doses of piperacillin-tazobactam may be a reasonable method to compensate for drug loss due to residual volumes in large-bore intravenous pump tubing.

Original languageSpanish
Pages (from-to)886-891
Number of pages6
JournalAnnals of Pharmacotherapy
Volume47
Issue number6
DOIs
StatePublished - Jun 1 2013

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Infusion Pumps
Residual Volume
Pharmaceutical Preparations
Equipment Design
Lactams
Piperacillin
Intravenous Infusions
MEDLINE
Intravenous Injections
Publications
tazobactam drug combination piperacillin

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

El uso de altas dosis para compensar residuos en la sonda de infusiones continuas de piperacilina-tazobactam. / Lam, Wendy J.; Bhowmick, Tanaya; Gross, Alan; VanSchooneveld, Trevor C; Weinstein, Melvin P.

In: Annals of Pharmacotherapy, Vol. 47, No. 6, 01.06.2013, p. 886-891.

Research output: Contribution to journalArticle

Lam, Wendy J. ; Bhowmick, Tanaya ; Gross, Alan ; VanSchooneveld, Trevor C ; Weinstein, Melvin P. / El uso de altas dosis para compensar residuos en la sonda de infusiones continuas de piperacilina-tazobactam. In: Annals of Pharmacotherapy. 2013 ; Vol. 47, No. 6. pp. 886-891.
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abstract = "OBJECTIVE: To mathematically assess drug losses due to infusion line residuals and evaluate methods to compensate for drug loss due to residual volumes in intravenous pump tubing. DATA SOURCES: Literature was accessed through Ovid MEDLINE (1996-February 2013), using combinations of the search terms tubing residuals, residual volume, residual medication, intravenous infusions, intravenous injections, piperacillin, piperacillin-tazobactam, β-lactams, equipment design, infusion pumps, extended infusion, extended administration, and prolonged infusion. In addition, select reference citations from publications identified were reviewed. STUDY SELECTION AND DATA EXTRACTION: All articles that involved extended-infusion piperacillin-tazobactam implementation strategies were included in the review. DATA SYNTHESIS: Infusion pump characteristics and tubing residuals can affect extended-infusion piperacillin-tazobactam dosing strategies. Two studies addressing tubing residuals were identified. Both studies recommended increasing infusion volumes to compensate for tubing residuals. One study also recommended decreasing infusion-line dead space by using alternative infusion pump systems. Study calculations suggest that higher doses of piperacillin-tazobactam may be used to account for medication left in tubing residuals if alternative infusion pump systems cannot be obtained, and increased infusion volumes are not an option. CONCLUSIONS: Extended-infusion piperacillin-tazobactam has been used as a method of maximizing pharmacodynamic target attainment. Use of higher doses of piperacillin-tazobactam may be a reasonable method to compensate for drug loss due to residual volumes in large-bore intravenous pump tubing.",
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