Usefulness of surveillance cultures in neonatal extracorporeal membrane oxygenation

Lamia F. Elerian, John W. Sparks, Tory A. Meyer, Jay B. Zwischenberger, John Doski, Michael J. Goretsky, Brad W. Warner, Henry W. Cheu, Kevin P. Lally

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Sepsis is difficult to identify in patients treated with extracorporeal membrane oxygenation (ECMO). This study evaluates the usefulness of surveillance cultures obtained during ECMO. We retrospectively reviewed the records of 187 patients from four ECMO centers with birth weights 1,574 to 4,900 gm and gestational ages 33-43 weeks, over a 4 year interval. Most patients had surveillance blood cultures daily, and tracheal aspirates and urine culture every other day. Charts were reviewed for culture results before, during, and for the 7 days after ECMO, and clinical response to the culture results. A total of 2,423 cultures were obtained during 1,487 days of ECMO, of which 155 were positive (6.4%): 13 of 1,370 blood cultures (0.9%), 137 of 850 tracheal aspirate cultures (16%), and 5 of 203 urine cultures (2.3%). After 72 hours, tracheal aspirate cultures became positive with nosocomial organisms in 33 of 131 patients. None of 153 bacterial urine cultures were positive, and only one of 34 viral urine cultures were positive (CMV). We conclude that routine daily blood cultures are not useful in neonatal ECMO. Tracheal aspirate cultures may be helpful in the management of antibiotic therapy in patients on ECMO for more than 5 days. Routine bacterial urine cultures did not provide useful information.

Original languageEnglish (US)
Pages (from-to)220-223
Number of pages4
JournalASAIO Journal
Volume47
Issue number3
DOIs
StatePublished - Jan 1 2001

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Extracorporeal Membrane Oxygenation
Oxygenation
Membranes
Urine
Blood
Antibiotics
Birth Weight
Gestational Age
Sepsis
Anti-Bacterial Agents
Blood Culture

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Elerian, L. F., Sparks, J. W., Meyer, T. A., Zwischenberger, J. B., Doski, J., Goretsky, M. J., ... Lally, K. P. (2001). Usefulness of surveillance cultures in neonatal extracorporeal membrane oxygenation. ASAIO Journal, 47(3), 220-223. https://doi.org/10.1097/00002480-200105000-00012

Usefulness of surveillance cultures in neonatal extracorporeal membrane oxygenation. / Elerian, Lamia F.; Sparks, John W.; Meyer, Tory A.; Zwischenberger, Jay B.; Doski, John; Goretsky, Michael J.; Warner, Brad W.; Cheu, Henry W.; Lally, Kevin P.

In: ASAIO Journal, Vol. 47, No. 3, 01.01.2001, p. 220-223.

Research output: Contribution to journalArticle

Elerian, LF, Sparks, JW, Meyer, TA, Zwischenberger, JB, Doski, J, Goretsky, MJ, Warner, BW, Cheu, HW & Lally, KP 2001, 'Usefulness of surveillance cultures in neonatal extracorporeal membrane oxygenation', ASAIO Journal, vol. 47, no. 3, pp. 220-223. https://doi.org/10.1097/00002480-200105000-00012
Elerian, Lamia F. ; Sparks, John W. ; Meyer, Tory A. ; Zwischenberger, Jay B. ; Doski, John ; Goretsky, Michael J. ; Warner, Brad W. ; Cheu, Henry W. ; Lally, Kevin P. / Usefulness of surveillance cultures in neonatal extracorporeal membrane oxygenation. In: ASAIO Journal. 2001 ; Vol. 47, No. 3. pp. 220-223.
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