Usefulness of Pulmonary Arterial End-Diastolic Forward Flow Late After Tetralogy of Fallot Repair to Predict a “Restrictive” Right Ventricle

Shelby Kutty, Anne Marie Valente, Matthew T. White, Kelsey Hickey, David Alan Danford, Andrew J. Powell, Tal Geva

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The functional significance of pulmonary arterial end-diastolic forward flow (EDFF) in patients with repaired tetralogy of Fallot (rTOF) is not fully understood, with conflicting reports regarding its associations with pulmonary regurgitation (PR), right ventricular (RV) size and function, and so-called restrictive RV physiology. To examine these associations, we retrospectively analyzed 399 patients with rTOF who had contemporaneous echocardiography (Echo) and cardiovascular magnetic resonance (CMR) studies. The median age at TOF repair was 0.7 years (0.21, 2.66), age at CMR was 19.8 years (13.0, 29.4), and interval between Echo and CMR was 48 days (0, 182). Doppler identified EDFF in 122 (31%) patients and CMR in 113 patients (28%). Compared with those without EDFF, patients with EDFF were younger, had greater PR, and higher RV end-diastolic volume, stroke volume, and ejection fraction. Markers of RV restriction such as right atrial size did not differ between groups. On multivariable regression, EDFF was associated with higher RV stroke volume and lower left ventricular end-diastolic volume. The association between Echo and CMR measurements of EDFF was modest (area under the receiver operating characteristic curve = 0.684, r = 0.374, p < 0.001). In conclusion, EDFF was common in this large cohort of patients with rTOF, but its presence and extent varied between Echo and CMR. EDFF was associated with greater PR and larger RV size, but not with markers of poor RV compliance such as right atrial enlargement. Mechanisms beyond RV noncompliance may contribute to the presence of EDFF.

Original languageEnglish (US)
Pages (from-to)1380-1386
Number of pages7
JournalAmerican Journal of Cardiology
Volume121
Issue number11
DOIs
StatePublished - Jun 1 2018

Fingerprint

Tetralogy of Fallot
Heart Ventricles
Magnetic Resonance Spectroscopy
Pulmonary Valve Insufficiency
Stroke Volume
Lung
Echocardiography
Right Ventricular Function
ROC Curve
Compliance

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Usefulness of Pulmonary Arterial End-Diastolic Forward Flow Late After Tetralogy of Fallot Repair to Predict a “Restrictive” Right Ventricle. / Kutty, Shelby; Valente, Anne Marie; White, Matthew T.; Hickey, Kelsey; Danford, David Alan; Powell, Andrew J.; Geva, Tal.

In: American Journal of Cardiology, Vol. 121, No. 11, 01.06.2018, p. 1380-1386.

Research output: Contribution to journalArticle

Kutty, Shelby ; Valente, Anne Marie ; White, Matthew T. ; Hickey, Kelsey ; Danford, David Alan ; Powell, Andrew J. ; Geva, Tal. / Usefulness of Pulmonary Arterial End-Diastolic Forward Flow Late After Tetralogy of Fallot Repair to Predict a “Restrictive” Right Ventricle. In: American Journal of Cardiology. 2018 ; Vol. 121, No. 11. pp. 1380-1386.
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abstract = "The functional significance of pulmonary arterial end-diastolic forward flow (EDFF) in patients with repaired tetralogy of Fallot (rTOF) is not fully understood, with conflicting reports regarding its associations with pulmonary regurgitation (PR), right ventricular (RV) size and function, and so-called restrictive RV physiology. To examine these associations, we retrospectively analyzed 399 patients with rTOF who had contemporaneous echocardiography (Echo) and cardiovascular magnetic resonance (CMR) studies. The median age at TOF repair was 0.7 years (0.21, 2.66), age at CMR was 19.8 years (13.0, 29.4), and interval between Echo and CMR was 48 days (0, 182). Doppler identified EDFF in 122 (31{\%}) patients and CMR in 113 patients (28{\%}). Compared with those without EDFF, patients with EDFF were younger, had greater PR, and higher RV end-diastolic volume, stroke volume, and ejection fraction. Markers of RV restriction such as right atrial size did not differ between groups. On multivariable regression, EDFF was associated with higher RV stroke volume and lower left ventricular end-diastolic volume. The association between Echo and CMR measurements of EDFF was modest (area under the receiver operating characteristic curve = 0.684, r = 0.374, p < 0.001). In conclusion, EDFF was common in this large cohort of patients with rTOF, but its presence and extent varied between Echo and CMR. EDFF was associated with greater PR and larger RV size, but not with markers of poor RV compliance such as right atrial enlargement. Mechanisms beyond RV noncompliance may contribute to the presence of EDFF.",
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