Abstract
Myocardial contrast echocardiography has revealed that successful coronary angioplasty results in an immediate decrease in the amount of collateral blood flow to the perfusion bed supplied by the dilated vessel. This information could potentially be used with pharmacologic stress in the catheterization laboratory to also assess the improvement in coronary flow reserve after angioplasty. The immediate changes in area under the time intensity curve produced by a 1 ml stow injection of sonicated albumin immediately proximal to a stenosis before and after 14 angiographically successful angioplasties was studied in 12 patients. Area under the curve was assessed before and after an 8 mg selective injection of papaverine. The changes in area under the curve were correlated with percent improvement in epicardial area stenosis. Visually successful angioplasty resulted in >30% improvement in area under the curve after papaverine in 9 of 14 studies. There was a significant correlation between improvement in area under the curve after papaverine and percent improvement in epicardial area stenosis (r = 0.75; p < 0.01). No patient had left ventricular wall motion abnormalities after papaverine before or after angioplasty. These changes suggest that quantitatively successful angioplasty results in decreased collateral blood flow to the involved myocardium during pharmacologic stress. These improvements in coronary flow reserve cannot be predicted by visual analysis of angioplasty results.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 893-896 |
| Number of pages | 4 |
| Journal | The American Journal of Cardiology |
| Volume | 71 |
| Issue number | 11 |
| DOIs | |
| State | Published - Apr 15 1993 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Usefulness of myocardial contrast echocardipgraphy in detecting the immediate changes in anterograde blood flow reserve after coronary angioplasty. / Porter, Thomas R.; D'Sa, Alwyn; Pesko, Larry; Turner, Carroll; Nath, Amar; Vetrovec, George W.; Nixon, J. V.
In: The American Journal of Cardiology, Vol. 71, No. 11, 15.04.1993, p. 893-896.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Usefulness of myocardial contrast echocardipgraphy in detecting the immediate changes in anterograde blood flow reserve after coronary angioplasty
AU - Porter, Thomas R.
AU - D'Sa, Alwyn
AU - Pesko, Larry
AU - Turner, Carroll
AU - Nath, Amar
AU - Vetrovec, George W.
AU - Nixon, J. V.
PY - 1993/4/15
Y1 - 1993/4/15
N2 - Myocardial contrast echocardiography has revealed that successful coronary angioplasty results in an immediate decrease in the amount of collateral blood flow to the perfusion bed supplied by the dilated vessel. This information could potentially be used with pharmacologic stress in the catheterization laboratory to also assess the improvement in coronary flow reserve after angioplasty. The immediate changes in area under the time intensity curve produced by a 1 ml stow injection of sonicated albumin immediately proximal to a stenosis before and after 14 angiographically successful angioplasties was studied in 12 patients. Area under the curve was assessed before and after an 8 mg selective injection of papaverine. The changes in area under the curve were correlated with percent improvement in epicardial area stenosis. Visually successful angioplasty resulted in >30% improvement in area under the curve after papaverine in 9 of 14 studies. There was a significant correlation between improvement in area under the curve after papaverine and percent improvement in epicardial area stenosis (r = 0.75; p < 0.01). No patient had left ventricular wall motion abnormalities after papaverine before or after angioplasty. These changes suggest that quantitatively successful angioplasty results in decreased collateral blood flow to the involved myocardium during pharmacologic stress. These improvements in coronary flow reserve cannot be predicted by visual analysis of angioplasty results.
AB - Myocardial contrast echocardiography has revealed that successful coronary angioplasty results in an immediate decrease in the amount of collateral blood flow to the perfusion bed supplied by the dilated vessel. This information could potentially be used with pharmacologic stress in the catheterization laboratory to also assess the improvement in coronary flow reserve after angioplasty. The immediate changes in area under the time intensity curve produced by a 1 ml stow injection of sonicated albumin immediately proximal to a stenosis before and after 14 angiographically successful angioplasties was studied in 12 patients. Area under the curve was assessed before and after an 8 mg selective injection of papaverine. The changes in area under the curve were correlated with percent improvement in epicardial area stenosis. Visually successful angioplasty resulted in >30% improvement in area under the curve after papaverine in 9 of 14 studies. There was a significant correlation between improvement in area under the curve after papaverine and percent improvement in epicardial area stenosis (r = 0.75; p < 0.01). No patient had left ventricular wall motion abnormalities after papaverine before or after angioplasty. These changes suggest that quantitatively successful angioplasty results in decreased collateral blood flow to the involved myocardium during pharmacologic stress. These improvements in coronary flow reserve cannot be predicted by visual analysis of angioplasty results.
UR - http://www.scopus.com/inward/record.url?scp=0027463104&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027463104&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(93)90902-O
DO - 10.1016/0002-9149(93)90902-O
M3 - Article
C2 - 8465777
AN - SCOPUS:0027463104
VL - 71
SP - 893
EP - 896
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 11
ER -