Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors

Adam McQuistan, Anita J. Zaitouna, Elena Echeverria, Rebecca Y. Lai

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We incorporated short thiolated oligonucleotides as passivating diluents in the fabrication of electrochemical peptide-based (E-PB) sensors, with the goal of creating a negatively charged layer capable of resisting non-specific adsorption of matrix contaminants. The E-PB HIV sensors fabricated using these diluents were found to be more specific and selective, while retaining attributes similar to the sensor fabricated without these diluents. Overall, these results highlight the advantages of using oligonucleotides as anti-fouling diluents in self-assembled monolayer-based sensors. This journal is

Original languageEnglish (US)
Pages (from-to)4690-4692
Number of pages3
JournalChemical Communications
Volume50
Issue number36
DOIs
StatePublished - May 11 2014

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Oligonucleotides
Fouling
Peptides
Sensors
Self assembled monolayers
Impurities
Adsorption
Fabrication

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors. / McQuistan, Adam; Zaitouna, Anita J.; Echeverria, Elena; Lai, Rebecca Y.

In: Chemical Communications, Vol. 50, No. 36, 11.05.2014, p. 4690-4692.

Research output: Contribution to journalArticle

McQuistan, Adam ; Zaitouna, Anita J. ; Echeverria, Elena ; Lai, Rebecca Y. / Use of thiolated oligonucleotides as anti-fouling diluents in electrochemical peptide-based sensors. In: Chemical Communications. 2014 ; Vol. 50, No. 36. pp. 4690-4692.
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