Use of prognostic factors in improving the design and efficiency of clinical trials in childhood leukemia

Children's Cancer Study Group Report.

D. R. Miller, S. Leikin, V. Albo, L. Vitale, H. Sather, Peter Felix Coccia, M. Nesbit, M. Karon, D. Hammond

Research output: Contribution to journalArticle

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Abstract

Prognostic factors are exerting an increasingly apparent and important influence on the results of comparative treatment regimens in childhood leukemia. Since February 1975, 883 previously untreated children with acute lymphocytic leukemia were entered in a protocol designed to evaluate prognostic factors that influence induction rate, remission duration, and survival and to identify subsets of patients with a high risk of early failure. Stratification was based upon the initial wbc count, and standard and more intensive induction and maintenance therapy programs were compared. The combination of older age (> 10 years), high initial wbc counts (greater than or equal to 20 x 10(9)/liter), and low serum IgG is associated with a significantly lower rate of induction of complete remission. The following factors were associated with an unfavorable prognosis with regard to bone marrow relapse and death: wbc count of greater than or equal to 20 x 10(9)/liter; age > 7 years old; CNS disease at diagnosis; L2 lymphoblasts; hemoglobin level greater than or equal to 11 g/dl; decreased concentration of serum immunoglobulin; and M3 marrow on Day 14 of induction. None of the 41 patients in the low-risk prognostic group (3-7 years old with an initial wbc count of < 10 x 10(9)/liter) with L1 blast cells, normal Ig, and M1 marrow on Day 14 has sustained an adverse event. Identification of prognostic factors should permit more efficient and effective design of future protocols by refining the classification of acute lymphocytic leukemia, decreasing the toxic risk to patients with a better prognosis, and improving the relatively poor remission duration and survival for patients with a poor prognosis.

Original languageEnglish (US)
Pages (from-to)381-392
Number of pages12
JournalCancer Treatment Reports
Volume64
Issue number2-3
StatePublished - Feb 1 1980

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Leukemia
Clinical Trials
Remission Induction
Neoplasms
Bone Marrow
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Survival
Poisons
Central Nervous System Diseases
Serum
Immunoglobulins
Hemoglobins
Immunoglobulin G
Recurrence
Therapeutics

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Miller, D. R., Leikin, S., Albo, V., Vitale, L., Sather, H., Coccia, P. F., ... Hammond, D. (1980). Use of prognostic factors in improving the design and efficiency of clinical trials in childhood leukemia: Children's Cancer Study Group Report. Cancer Treatment Reports, 64(2-3), 381-392.

Use of prognostic factors in improving the design and efficiency of clinical trials in childhood leukemia : Children's Cancer Study Group Report. / Miller, D. R.; Leikin, S.; Albo, V.; Vitale, L.; Sather, H.; Coccia, Peter Felix; Nesbit, M.; Karon, M.; Hammond, D.

In: Cancer Treatment Reports, Vol. 64, No. 2-3, 01.02.1980, p. 381-392.

Research output: Contribution to journalArticle

Miller, DR, Leikin, S, Albo, V, Vitale, L, Sather, H, Coccia, PF, Nesbit, M, Karon, M & Hammond, D 1980, 'Use of prognostic factors in improving the design and efficiency of clinical trials in childhood leukemia: Children's Cancer Study Group Report.', Cancer Treatment Reports, vol. 64, no. 2-3, pp. 381-392.
Miller, D. R. ; Leikin, S. ; Albo, V. ; Vitale, L. ; Sather, H. ; Coccia, Peter Felix ; Nesbit, M. ; Karon, M. ; Hammond, D. / Use of prognostic factors in improving the design and efficiency of clinical trials in childhood leukemia : Children's Cancer Study Group Report. In: Cancer Treatment Reports. 1980 ; Vol. 64, No. 2-3. pp. 381-392.
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