Use of high-performance liquid chromatography for determination of urate concentrations in nanoliter quantities of fluid

E. J. Weinman, D. Steplock, S. C. Sansom, T. F. Knight, H. O. Senekjian

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Abstract

The results reported in this communication indicate excellent agreement between the calculated values for urate concentrations determined from isotope counting and that determined chemically by high performance liquid chromatography (HPLC). These findings suggest that, under appropriate experimental conditions, the isotope flux accurately predicts the chemical flux of urate, and the exchange of unlabeled for labeled urate is not a significant variable. The use of HPLC therefore appears to be a most promising new microanalytical tool with which to elucidate the mechanisms subserving the tubular absorption and secretion of urate.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalUnknown Journal
Volume19
Issue number1
DOIs
Publication statusPublished - Jan 1 1981

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ASJC Scopus subject areas

  • Nephrology

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