UROTHELIAL CHANGES OF THE RENAL PAPILLAE IN SPRAGUE‐DAWLEY RATS INDUCED BY LONG TERM FEEDING OF PHENACETIN

Sonny Johansson, Lennart Angervall

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Thirty female Sprague‐Dawley rats were fed 0.535 per cent phenacetin in the diet for up to 110 weeks. Twenty‐six of these rats developed urothelial hyperplasia, partly papillary, of the renal papillae. Twenty‐eight rats showed dilatation of the vasa recta frequently associated with thrombus formation and calcification. One phenacetin fed rat had epithelial hyperplasia associated with chronic pyelitis. In 2 of the 30 control rats urothelial hyperplasia was found to be associated with chronic pyelitis. The hyperplastic urothelial changes and vascular changes were often, but not always, present simultaneously. One control rat developed a mammary carcinoma, as compared with 5 rats in the phenacetin group. Four phenacetin fed rats developed carcinoma of the ear duct. The results of the present investigation provide evidence that phenacetin can induce proliferative lesions of the urothelium of the rat renal pelvis with weak carcinogenic activity in the ear duct and mammary glands. 1976 Acta Pathologica, Microbiologica et Immunologica Scandinavica

Original languageEnglish (US)
Pages (from-to)375-383
Number of pages9
JournalActa Pathologica Microbiologica Scandinavica Section A Pathology
Volume84 A
Issue number5
DOIs
Publication statusPublished - Jul 1976

    Fingerprint

Keywords

  • Urothelial changes
  • phenacetin
  • rats

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

Cite this