Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt

Subhojit Dey, Amr S. Soliman, Ahmad Hablas, Ibrahim A. Seifeldin, Kadry Ismail, Mohamed Ramadan, Hesham El-Hamzawy, Mark L. Wilson, Mousumi Banerjee, Paolo Boffetta, Joe Harford, Sofia D. Merajver

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Breast cancer incidence is higher in developed countries with higher rates of estrogen receptor positive (ER+) tumors. ER+ tumors are caused by estrogenic exposures although known exposures explain approximately 50% of breast cancer risk. Unknown risk factors causing high breast cancer incidence exist that are estrogenic and development-related. Xenoestrogens are such risk factors but are difficult to study since developed countries lack unexposed populations. Developing countries have urban-rural populations with differential exposure to xenoestrogens. This study assessed urban-rural breast cancer incidence classified by hormone receptor status using data from Gharbiah population-based cancer registry in Egypt from 2001 to 2006. Urban ER+ incidence rate (per 100,000 women) was 2-4 times (IRR = 3.36, 95% CI = 4.84, 2.34) higher than rural incidence rate. ER-incidence rate was 2-3 times (IRR = 1.86, 95% CI = 2.38, 1.45) higher in urban areas than in rural areas. Our findings indicate that urban women may probably have a higher exposure to xenoestrogens.

Original languageEnglish (US)
Pages (from-to)149-160
Number of pages12
JournalBreast Cancer Research and Treatment
Volume120
Issue number1
DOIs
StatePublished - Feb 1 2010

Fingerprint

Egypt
Hormones
Breast Neoplasms
Incidence
Developed Countries
Neoplasms
Urban Population
Rural Population
Estrogen Receptors
Population
Developing Countries
Registries

Keywords

  • Breast cancer incidence
  • Egypt
  • Hormone receptor status
  • Mammary stem cells
  • Xenoestrogens

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Dey, S., Soliman, A. S., Hablas, A., Seifeldin, I. A., Ismail, K., Ramadan, M., ... Merajver, S. D. (2010). Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt. Breast Cancer Research and Treatment, 120(1), 149-160. https://doi.org/10.1007/s10549-009-0427-9

Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt. / Dey, Subhojit; Soliman, Amr S.; Hablas, Ahmad; Seifeldin, Ibrahim A.; Ismail, Kadry; Ramadan, Mohamed; El-Hamzawy, Hesham; Wilson, Mark L.; Banerjee, Mousumi; Boffetta, Paolo; Harford, Joe; Merajver, Sofia D.

In: Breast Cancer Research and Treatment, Vol. 120, No. 1, 01.02.2010, p. 149-160.

Research output: Contribution to journalArticle

Dey, S, Soliman, AS, Hablas, A, Seifeldin, IA, Ismail, K, Ramadan, M, El-Hamzawy, H, Wilson, ML, Banerjee, M, Boffetta, P, Harford, J & Merajver, SD 2010, 'Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt', Breast Cancer Research and Treatment, vol. 120, no. 1, pp. 149-160. https://doi.org/10.1007/s10549-009-0427-9
Dey, Subhojit ; Soliman, Amr S. ; Hablas, Ahmad ; Seifeldin, Ibrahim A. ; Ismail, Kadry ; Ramadan, Mohamed ; El-Hamzawy, Hesham ; Wilson, Mark L. ; Banerjee, Mousumi ; Boffetta, Paolo ; Harford, Joe ; Merajver, Sofia D. / Urban-rural differences in breast cancer incidence by hormone receptor status across 6 years in Egypt. In: Breast Cancer Research and Treatment. 2010 ; Vol. 120, No. 1. pp. 149-160.
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