Urban legends

Recurrent aphthous stomatitis

Lorena Baccaglini, Rv Lalla, Aj Bruce, Jc Sartori-Valinotti, Mc Latortue, M. Carrozzo, Rs Rogers

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Behçet's disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases [e.g., celiac disease (CD) and B12 deficiency]? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested the following: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty-three controlled trials published in the past 6years reported some effectiveness, although potential for bias was high.

Original languageEnglish (US)
Pages (from-to)755-770
Number of pages16
JournalOral Diseases
Volume17
Issue number8
DOIs
StatePublished - Nov 1 2011

Fingerprint

Aphthous Stomatitis
Oral Ulcer
Lymphadenitis
Pharyngitis
Celiac Disease
Fever
North America
Ulcer
Sutton disease 2
Pain
Therapeutics
Pharmaceutical Preparations

Keywords

  • Aphthous stomatitis
  • Behçet syndrome
  • Celiac disease
  • Pharyngitis
  • Therapy
  • Vitamin B12

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

Baccaglini, L., Lalla, R., Bruce, A., Sartori-Valinotti, J., Latortue, M., Carrozzo, M., & Rogers, R. (2011). Urban legends: Recurrent aphthous stomatitis. Oral Diseases, 17(8), 755-770. https://doi.org/10.1111/j.1601-0825.2011.01840.x

Urban legends : Recurrent aphthous stomatitis. / Baccaglini, Lorena; Lalla, Rv; Bruce, Aj; Sartori-Valinotti, Jc; Latortue, Mc; Carrozzo, M.; Rogers, Rs.

In: Oral Diseases, Vol. 17, No. 8, 01.11.2011, p. 755-770.

Research output: Contribution to journalArticle

Baccaglini, L, Lalla, R, Bruce, A, Sartori-Valinotti, J, Latortue, M, Carrozzo, M & Rogers, R 2011, 'Urban legends: Recurrent aphthous stomatitis', Oral Diseases, vol. 17, no. 8, pp. 755-770. https://doi.org/10.1111/j.1601-0825.2011.01840.x
Baccaglini L, Lalla R, Bruce A, Sartori-Valinotti J, Latortue M, Carrozzo M et al. Urban legends: Recurrent aphthous stomatitis. Oral Diseases. 2011 Nov 1;17(8):755-770. https://doi.org/10.1111/j.1601-0825.2011.01840.x
Baccaglini, Lorena ; Lalla, Rv ; Bruce, Aj ; Sartori-Valinotti, Jc ; Latortue, Mc ; Carrozzo, M. ; Rogers, Rs. / Urban legends : Recurrent aphthous stomatitis. In: Oral Diseases. 2011 ; Vol. 17, No. 8. pp. 755-770.
@article{d7522b2b2ce3411cb0b836e95c3d7c15,
title = "Urban legends: Recurrent aphthous stomatitis",
abstract = "Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Beh{\cc}et's disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases [e.g., celiac disease (CD) and B12 deficiency]? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested the following: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty-three controlled trials published in the past 6years reported some effectiveness, although potential for bias was high.",
keywords = "Aphthous stomatitis, Beh{\cc}et syndrome, Celiac disease, Pharyngitis, Therapy, Vitamin B12",
author = "Lorena Baccaglini and Rv Lalla and Aj Bruce and Jc Sartori-Valinotti and Mc Latortue and M. Carrozzo and Rs Rogers",
year = "2011",
month = "11",
day = "1",
doi = "10.1111/j.1601-0825.2011.01840.x",
language = "English (US)",
volume = "17",
pages = "755--770",
journal = "Oral Diseases",
issn = "1354-523X",
publisher = "Wiley-Blackwell",
number = "8",

}

TY - JOUR

T1 - Urban legends

T2 - Recurrent aphthous stomatitis

AU - Baccaglini, Lorena

AU - Lalla, Rv

AU - Bruce, Aj

AU - Sartori-Valinotti, Jc

AU - Latortue, Mc

AU - Carrozzo, M.

AU - Rogers, Rs

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Behçet's disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases [e.g., celiac disease (CD) and B12 deficiency]? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested the following: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty-three controlled trials published in the past 6years reported some effectiveness, although potential for bias was high.

AB - Recurrent aphthous stomatitis (RAS) is the most common idiopathic intraoral ulcerative disease in the USA. Aphthae typically occur in apparently healthy individuals, although an association with certain systemic diseases has been reported. Despite the unclear etiopathogenesis, new drug trials are continuously conducted in an attempt to reduce pain and dysfunction. We investigated four controversial topics: (1) Is complex aphthosis a mild form of Behçet's disease (BD)? (2) Is periodic fever, aphthous stomatitis, pharyngitis, and adenitis (PFAPA) syndrome a distinct medical entity? (3) Is RAS associated with other systemic diseases [e.g., celiac disease (CD) and B12 deficiency]? (4) Are there any new RAS treatments? Results from extensive literature searches, including a systematic review of RAS trials, suggested the following: (1) Complex aphthosis is not a mild form of BD in North America or Western Europe; (2) Diagnostic criteria for PFAPA have low specificity and the characteristics of the oral ulcers warrant further studies; (3) Oral ulcers may be associated with CD; however, these ulcers may not be RAS; RAS is rarely associated with B12 deficiency; nevertheless, B12 treatment may be beneficial, via mechanisms that warrant further study; (4) Thirty-three controlled trials published in the past 6years reported some effectiveness, although potential for bias was high.

KW - Aphthous stomatitis

KW - Behçet syndrome

KW - Celiac disease

KW - Pharyngitis

KW - Therapy

KW - Vitamin B12

UR - http://www.scopus.com/inward/record.url?scp=80054080447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054080447&partnerID=8YFLogxK

U2 - 10.1111/j.1601-0825.2011.01840.x

DO - 10.1111/j.1601-0825.2011.01840.x

M3 - Article

VL - 17

SP - 755

EP - 770

JO - Oral Diseases

JF - Oral Diseases

SN - 1354-523X

IS - 8

ER -